Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-RelB |
| Location | 315219..315805 | Replicon | chromosome |
| Accession | NZ_CP092510 | ||
| Organism | Salmonella enterica subsp. enterica serovar Thompson | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | A0A5V1HI31 |
| Locus tag | MKE90_RS01445 | Protein ID | WP_000174965.1 |
| Coordinates | 315437..315805 (+) | Length | 123 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | A0A8F2ZY79 |
| Locus tag | MKE90_RS01440 | Protein ID | WP_001599562.1 |
| Coordinates | 315219..315440 (+) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MKE90_RS01415 (310239) | 310239..311348 | + | 1110 | WP_000822976.1 | high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK | - |
| MKE90_RS01420 (311408) | 311408..312334 | + | 927 | WP_000003007.1 | high-affinity branched-chain amino acid ABC transporter permease LivH | - |
| MKE90_RS01425 (312331) | 312331..313608 | + | 1278 | WP_000803764.1 | branched chain amino acid ABC transporter permease LivM | - |
| MKE90_RS01430 (313605) | 313605..314372 | + | 768 | WP_017465331.1 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG | - |
| MKE90_RS01435 (314374) | 314374..315087 | + | 714 | WP_000416114.1 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF | - |
| MKE90_RS01440 (315219) | 315219..315440 | + | 222 | WP_001599562.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| MKE90_RS01445 (315437) | 315437..315805 | + | 369 | WP_000174965.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| MKE90_RS01450 (316064) | 316064..317380 | + | 1317 | WP_017465332.1 | sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB | - |
| MKE90_RS01455 (317485) | 317485..318372 | + | 888 | WP_000094074.1 | sn-glycerol-3-phosphate ABC transporter permease UgpA | - |
| MKE90_RS01460 (318369) | 318369..319214 | + | 846 | WP_000572196.1 | sn-glycerol-3-phosphate ABC transporter permease UgpE | - |
| MKE90_RS01465 (319216) | 319216..320286 | + | 1071 | WP_000907838.1 | sn-glycerol-3-phosphate import ATP-binding protein UgpC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 312331..321023 | 8692 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 123 a.a. Molecular weight: 13599.89 Da Isoelectric Point: 6.4657
>T236331 WP_000174965.1 NZ_CP092510:315437-315805 [Salmonella enterica subsp. enterica serovar Thompson]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLAISRGYIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIAVRLRA
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLAISRGYIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIAVRLRA
Download Length: 369 bp
>T236331 NZ_LR536431:1172435-1172776 [Escherichia coli]
ATGTGGCTGTTTACTTACTATAAGGAAGTTAAAAACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCC
TAACGACGCTCTGGCTCTTCAGGCATTGTATCGGGTTATTAAGGAAACGGATTTTTCTACGCCAGAAGAGATGCGAACGG
CGTTTCCCAACCTCGACAATTTTAAATATCGCAACAAATGGTACGTTCTGGATGTAGGTGGGAACAACCTAAGGGTGATT
GCCTACATAAACTTTGTTAATAAGCGGTTCTTTGTGAAGCACATAACTAATCACGCCGAGTATGACAAACTGACACGTTA
CTACAGAGAGAACAAAGAATGA
ATGTGGCTGTTTACTTACTATAAGGAAGTTAAAAACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCC
TAACGACGCTCTGGCTCTTCAGGCATTGTATCGGGTTATTAAGGAAACGGATTTTTCTACGCCAGAAGAGATGCGAACGG
CGTTTCCCAACCTCGACAATTTTAAATATCGCAACAAATGGTACGTTCTGGATGTAGGTGGGAACAACCTAAGGGTGATT
GCCTACATAAACTTTGTTAATAAGCGGTTCTTTGTGAAGCACATAACTAATCACGCCGAGTATGACAAACTGACACGTTA
CTACAGAGAGAACAAAGAATGA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8151.20 Da Isoelectric Point: 6.4643
>AT236331 WP_001599562.1 NZ_CP092510:315219-315440 [Salmonella enterica subsp. enterica serovar Thompson]
MRTVNYSEARQNLAEVLESAVTGGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRKLADK
MRTVNYSEARQNLAEVLESAVTGGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRKLADK
Download Length: 222 bp
>AT236331 NZ_LR536431:1172773-1173192 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGTAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAACAACCAAGAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCTGTT
GGCGTGGCGTTACTTCGCACGCTGATTGATCAACATAATCTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGTCAGATTTTGTCTGGACAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGTAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAACAACCAAGAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCTGTT
GGCGTGGCGTTACTTCGCACGCTGATTGATCAACATAATCTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGTCAGATTTTGTCTGGACAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|