Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 204926..205686 Replicon chromosome
Accession NZ_CP092510
Organism Salmonella enterica subsp. enterica serovar Thompson

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag MKE90_RS00955 Protein ID WP_000533909.1
Coordinates 205201..205686 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag MKE90_RS00950 Protein ID WP_000965886.1
Coordinates 204926..205213 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKE90_RS00930 (200331) 200331..201242 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
MKE90_RS00935 (201252) 201252..203321 + 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
MKE90_RS00940 (203711) 203711..204109 + 399 Protein_186 IS3 family transposase -
MKE90_RS00945 (204281) 204281..204748 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
MKE90_RS00950 (204926) 204926..205213 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
MKE90_RS00955 (205201) 205201..205686 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
MKE90_RS00960 (206060) 206060..206599 - 540 WP_000047140.1 copper-binding periplasmic metallochaperone CueP -
MKE90_RS00965 (206772) 206772..206984 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
MKE90_RS00970 (207272) 207272..207562 - 291 WP_000455790.1 HTH-type transcriptional regulator -
MKE90_RS00975 (208001) 208001..208711 + 711 WP_000190524.1 DUF3053 domain-containing protein -
MKE90_RS00980 (208761) 208761..209735 - 975 WP_017465308.1 glyoxylate/hydroxypyruvate reductase GhrB -
MKE90_RS00985 (209954) 209954..210616 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T236330 WP_000533909.1 NZ_CP092510:205201-205686 [Salmonella enterica subsp. enterica serovar Thompson]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T236330 NZ_LR536431:1059991-1060326 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT236330 WP_000965886.1 NZ_CP092510:204926-205213 [Salmonella enterica subsp. enterica serovar Thompson]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT236330 NZ_LR536431:1059743-1059991 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References