Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2887289..2888003 Replicon chromosome
Accession NC_012207
Organism Mycobacterium bovis BCG str. Tokyo 172

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag JTY_RS13525 Protein ID WP_003413460.1
Coordinates 2887563..2888003 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag JTY_RS13520 Protein ID WP_003413456.1
Coordinates 2887289..2887576 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JTY_RS13485 2882721..2882966 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
JTY_RS13490 2882963..2883367 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
JTY_RS13495 2883584..2884204 + 621 WP_003413441.1 DUF4178 domain-containing protein -
JTY_RS13500 2884215..2884709 + 495 WP_003413444.1 DUF2617 family protein -
JTY_RS13505 2884706..2885137 + 432 WP_003413445.1 DUF4247 domain-containing protein -
JTY_RS13510 2885162..2885610 + 449 Protein_2628 DUF350 domain-containing protein -
JTY_RS13515 2885607..2887178 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
JTY_RS13520 2887289..2887576 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
JTY_RS13525 2887563..2888003 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
JTY_RS13530 2888024..2888779 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
JTY_RS13535 2888912..2889508 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
JTY_RS13540 2889516..2890361 - 846 WP_010950749.1 acyl-CoA thioesterase II -
JTY_RS13545 2890390..2891289 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
JTY_RS13550 2891417..2892091 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T23633 WP_003413460.1 NC_012207:2887563-2888003 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T23633 NC_012207:2887563-2888003 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT23633 WP_003413456.1 NC_012207:2887289-2887576 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT23633 NC_012207:2887289-2887576 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References