Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3305817..3306435 Replicon chromosome
Accession NZ_CP092500
Organism Escherichia coli strain A30

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag LU695_RS16520 Protein ID WP_001291435.1
Coordinates 3306217..3306435 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag LU695_RS16515 Protein ID WP_000344800.1
Coordinates 3305817..3306191 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LU695_RS16505 (3301346) 3301346..3304495 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
LU695_RS16515 (3305817) 3305817..3306191 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
LU695_RS16520 (3306217) 3306217..3306435 + 219 WP_001291435.1 HHA domain-containing protein Toxin
LU695_RS16525 (3306607) 3306607..3307158 + 552 WP_000102569.1 maltose O-acetyltransferase -
LU695_RS16530 (3307274) 3307274..3307744 + 471 WP_000136192.1 YlaC family protein -
LU695_RS16535 (3307908) 3307908..3309458 + 1551 WP_258313938.1 cyclic-guanylate-specific phosphodiesterase PdeB -
LU695_RS16540 (3309500) 3309500..3309853 - 354 WP_000878140.1 DUF1428 domain-containing protein -
LU695_RS16550 (3310232) 3310232..3310543 + 312 WP_000409911.1 MGMT family protein -
LU695_RS16555 (3310574) 3310574..3311146 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3304639..3305142 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T236324 WP_001291435.1 NZ_CP092500:3306217-3306435 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T236324 NZ_LR536430:4920226-4920480 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT236324 WP_000344800.1 NZ_CP092500:3305817-3306191 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT236324 NZ_LR536430:4919978-4920229 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References