Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2293802..2294440 Replicon chromosome
Accession NZ_CP092500
Organism Escherichia coli strain A30

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LU695_RS11290 Protein ID WP_100287188.1
Coordinates 2294264..2294440 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LU695_RS11285 Protein ID WP_001270286.1
Coordinates 2293802..2294218 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LU695_RS11265 (2288954) 2288954..2289895 - 942 WP_258313813.1 ABC transporter permease -
LU695_RS11270 (2289896) 2289896..2290909 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
LU695_RS11275 (2290927) 2290927..2292072 - 1146 WP_100287187.1 ABC transporter substrate-binding protein -
LU695_RS11280 (2292317) 2292317..2293723 - 1407 WP_258313814.1 PLP-dependent aminotransferase family protein -
LU695_RS11285 (2293802) 2293802..2294218 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
LU695_RS11290 (2294264) 2294264..2294440 - 177 WP_100287188.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
LU695_RS11295 (2294662) 2294662..2294892 + 231 WP_000494244.1 YncJ family protein -
LU695_RS11300 (2294984) 2294984..2296945 - 1962 WP_100287189.1 23S rRNA 5-hydroxycytidine C2501 synthase -
LU695_RS11305 (2297018) 2297018..2297554 - 537 WP_000429141.1 DNA-binding transcriptional regulator SutR -
LU695_RS11310 (2297646) 2297646..2298821 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2298861..2300009 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6808.90 Da        Isoelectric Point: 11.5336

>T236323 WP_100287188.1 NZ_CP092500:c2294440-2294264 [Escherichia coli]
VKQSEFRRWLESQGVDVANGRNHLKLRFHGRRSVMPRHSCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T236323 NZ_LR536430:4919978-4920229 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT236323 WP_001270286.1 NZ_CP092500:c2294218-2293802 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT236323 NZ_LR536430:4920226-4920480 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References