236298

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 4794763..4795429 Replicon chromosome
Accession NZ_CP092493
Organism Citrobacter freundii strain SCLZS47

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag MJ253_RS23810 Protein ID WP_134214823.1
Coordinates 4795070..4795429 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag MJ253_RS23805 Protein ID WP_134214821.1
Coordinates 4794763..4795080 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJ253_RS23765 (4790174) 4790174..4790491 - 318 WP_054527950.1 CcdB family protein -
MJ253_RS23770 (4790491) 4790491..4790784 - 294 WP_003844689.1 type II toxin-antitoxin system CcdA family antitoxin -
MJ253_RS23775 (4790881) 4790881..4791246 - 366 WP_134214819.1 hypothetical protein -
MJ253_RS23780 (4791378) 4791378..4791551 + 174 WP_032938222.1 hypothetical protein -
MJ253_RS23785 (4791685) 4791685..4791939 + 255 Protein_4672 transposase -
MJ253_RS23790 (4792170) 4792170..4793510 + 1341 WP_008786676.1 IS110 family transposase -
MJ253_RS23795 (4793524) 4793524..4794441 + 918 Protein_4674 IS3 family transposase -
MJ253_RS23800 (4794462) 4794462..4794623 + 162 WP_003841416.1 phage protein -
MJ253_RS23805 (4794763) 4794763..4795080 - 318 WP_134214821.1 helix-turn-helix transcriptional regulator Antitoxin
MJ253_RS23810 (4795070) 4795070..4795429 - 360 WP_134214823.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MJ253_RS23815 (4795643) 4795643..4796332 + 690 WP_003841421.1 dipeptidase PepE -
MJ253_RS23820 (4796479) 4796479..4798110 - 1632 WP_134214825.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-87)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13456.53 Da        Isoelectric Point: 10.2555

>T236298 WP_134214823.1 NZ_CP092493:c4795429-4795070 [Citrobacter freundii]
MTKPLYWVGQARKDLLAMPEHVRDTFGFAFWLAQQGKQHSQTKPLKGFGGAGVLEVVEDYHGSAWRAVYTIQLKNAVYVL
HVFQKKSVSGKATPKPEIDLIYQRLKAAQRHAQESGYVI

Download         Length: 360 bp

>T236298 NZ_LR217818:c4344180-4343806 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCACTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCCA
CAACTACAGAACGGTGAACAATATCACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11504.44 Da        Isoelectric Point: 8.9375

>AT236298 WP_134214821.1 NZ_CP092493:c4795080-4794763 [Citrobacter freundii]
MSYEVEASSGNVYVDLGAYDAEQMQLKAQLAMVIGEILQRKGLTQQQAAQLLGMTQPKLSNLLRGQFRGISEAKMLECLV
RLGRDVEIVVGKEGNMSGKLKVKFG

Download         Length: 318 bp

>AT236298 NZ_LR217818:c4344638-4344270 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGTCTGACCTGCAAAGCTGACACCCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References