Detailed information of TA system TA236295

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4414791..4415307
• Replicon: chromosome
• Accession: NZ_CP092493
• Organism: Citrobacter freundii strain SCLZS47

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0D7LMW6
• Locus tag: MJ253_RS21845
• Protein ID: WP_003839578.1
• Coordinates: 4414791..4415075 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MJ253_RS21850
• Protein ID: WP_134216310.1
• Coordinates: 4415065..4415307 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MJ253_RS21830 (4411116)	4411116..4411700	+	585	WP_003839584.1	fructose PTS transporter subunit IIA	-
MJ253_RS21835 (4412078)	4412078..4414216	+	2139	WP_003025782.1	anaerobic ribonucleoside-triphosphate reductase	-
MJ253_RS21840 (4414323)	4414323..4414787	+	465	WP_032937736.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
MJ253_RS21845 (4414791)	4414791..4415075	-	285	WP_003839578.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MJ253_RS21850 (4415065)	4415065..4415307	-	243	WP_134216310.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
MJ253_RS21855 (4415385)	4415385..4417298	-	1914	WP_134216312.1	BglG family transcription antiterminator	-
MJ253_RS21860 (4417320)	4417320..4418060	-	741	WP_048216922.1	KDGP aldolase family protein	-
MJ253_RS21865 (4418057)	4418057..4419175	-	1119	WP_003025770.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
MJ253_RS21870 (4419159)	4419159..4420292	-	1134	WP_016149471.1	amidohydrolase/deacetylase family metallohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-68)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10866.68 Da
• Isoelectric Point: 10.0482

>T236295 WP_003839578.1 NZ_CP092493:c4415075-4414791 [Citrobacter freundii]
MTYELEFDPRALKEWHKLGDTVKAQFKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVTVFVVAVGK
REHSAVYLDANKRL

Nucleotide

• Length: 285 bp

>T236295 NZ_LR217818:c3395368-3395114 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8963.38 Da
• Isoelectric Point: 5.0649

>AT236295 WP_134216310.1 NZ_CP092493:c4415307-4415065 [Citrobacter freundii]
MATLNVRLDDKLKNEAYAVLEKLNITPSEAVRLLFQYVAETGRMPVKTVTVSDCEDTLIQTVRERLASPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT236295 NZ_LR217818:c3395616-3395365 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Structures

Toxin

• AlphaFold DB: A0A0D7LMW6