Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 4344614..4345335 Replicon chromosome
Accession NZ_CP092493
Organism Citrobacter freundii strain SCLZS47

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag MJ253_RS21515 Protein ID WP_063149808.1
Coordinates 4344614..4344955 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag MJ253_RS21520 Protein ID WP_080460847.1
Coordinates 4344991..4345335 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJ253_RS21485 (4340630) 4340630..4340992 + 363 WP_003837149.1 endoribonuclease SymE -
MJ253_RS21490 (4341151) 4341151..4342023 + 873 WP_134216258.1 HNH endonuclease -
MJ253_RS21495 (4342152) 4342152..4342946 - 795 WP_134216261.1 helix-turn-helix transcriptional regulator -
MJ253_RS21500 (4343062) 4343062..4343337 - 276 WP_063149810.1 type II toxin-antitoxin system RelE/ParE family toxin -
MJ253_RS21505 (4343341) 4343341..4343589 - 249 WP_000535213.1 ribbon-helix-helix domain-containing protein -
MJ253_RS21510 (4343666) 4343666..4344499 - 834 WP_063149809.1 DUF4942 domain-containing protein -
MJ253_RS21515 (4344614) 4344614..4344955 - 342 WP_063149808.1 TA system toxin CbtA family protein Toxin
MJ253_RS21520 (4344991) 4344991..4345335 - 345 WP_080460847.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MJ253_RS21525 (4345359) 4345359..4345580 - 222 WP_063149807.1 DUF987 family protein -
MJ253_RS21530 (4345528) 4345528..4346064 - 537 WP_080460846.1 DNA repair protein RadC -
MJ253_RS21535 (4346134) 4346134..4346952 - 819 WP_172616074.1 DUF932 domain-containing protein -
MJ253_RS21540 (4347092) 4347092..4347343 - 252 WP_063149806.1 DUF905 family protein -
MJ253_RS21545 (4347340) 4347340..4348011 - 672 WP_063149805.1 hypothetical protein -
MJ253_RS21550 (4348194) 4348194..4348583 - 390 WP_063149804.1 hypothetical protein -
MJ253_RS21555 (4348580) 4348580..4349302 - 723 WP_232051960.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(14-113)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12865.79 Da        Isoelectric Point: 9.8519

>T236294 WP_063149808.1 NZ_CP092493:c4344955-4344614 [Citrobacter freundii]
MKAFPATNQRVAKPCPSPVAVWQMLLTRLLAQHYGLTLNDTPFNDESVIQEHINAGITLADAVNFLVEKNELVRIDRRGF
SWQEQSPYLRAVDILRARQATGLLRQSHNLLTR

Download         Length: 342 bp

>T236294 NZ_LR217818:3377762-3378136 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCCA
CAACTACAGAACGGTGAACAATATCACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13074.13 Da        Isoelectric Point: 8.7074

>AT236294 WP_080460847.1 NZ_CP092493:c4345335-4344991 [Citrobacter freundii]
MKKDTANEVMDTLQWGLKCDITPHFGARLAQEGNRLHYLADRASIIGQFSKADLRHLNQAFPLLMKHMELMLTSGELNPR
HQHRVTLYAKRLTCEVDTLGSCGYVYIAIYPTQR

Download         Length: 345 bp

>AT236294 NZ_LR217818:3377304-3377672 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References