236293

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 4343062..4343589 Replicon chromosome
Accession NZ_CP092493
Organism Citrobacter freundii strain SCLZS47

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MJ253_RS21500 Protein ID WP_063149810.1
Coordinates 4343062..4343337 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A941UEC5
Locus tag MJ253_RS21505 Protein ID WP_000535213.1
Coordinates 4343341..4343589 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJ253_RS21480 (4338481) 4338481..4339851 - 1371 WP_003837154.1 tyrosine phenol-lyase -
MJ253_RS21485 (4340630) 4340630..4340992 + 363 WP_003837149.1 endoribonuclease SymE -
MJ253_RS21490 (4341151) 4341151..4342023 + 873 WP_134216258.1 HNH endonuclease -
MJ253_RS21495 (4342152) 4342152..4342946 - 795 WP_134216261.1 helix-turn-helix transcriptional regulator -
MJ253_RS21500 (4343062) 4343062..4343337 - 276 WP_063149810.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MJ253_RS21505 (4343341) 4343341..4343589 - 249 WP_000535213.1 ribbon-helix-helix domain-containing protein Antitoxin
MJ253_RS21510 (4343666) 4343666..4344499 - 834 WP_063149809.1 DUF4942 domain-containing protein -
MJ253_RS21515 (4344614) 4344614..4344955 - 342 WP_063149808.1 TA system toxin CbtA family protein -
MJ253_RS21520 (4344991) 4344991..4345335 - 345 WP_080460847.1 type IV toxin-antitoxin system YeeU family antitoxin -
MJ253_RS21525 (4345359) 4345359..4345580 - 222 WP_063149807.1 DUF987 family protein -
MJ253_RS21530 (4345528) 4345528..4346064 - 537 WP_080460846.1 DNA repair protein RadC -
MJ253_RS21535 (4346134) 4346134..4346952 - 819 WP_172616074.1 DUF932 domain-containing protein -
MJ253_RS21540 (4347092) 4347092..4347343 - 252 WP_063149806.1 DUF905 family protein -
MJ253_RS21545 (4347340) 4347340..4348011 - 672 WP_063149805.1 hypothetical protein -
MJ253_RS21550 (4348194) 4348194..4348583 - 390 WP_063149804.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-42)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10942.30 Da        Isoelectric Point: 5.1546

>T236293 WP_063149810.1 NZ_CP092493:c4343337-4343062 [Citrobacter freundii]
MEVYWTLKAQDDLERIYRFALQYSRQHADDVLDGLITGCAGLKAHPAIGVQQTRYEPREVRKVLFDNYEVHYELRENDIY
IVDLWHTKEER

Download         Length: 276 bp

>T236293 NZ_LR217818:c3186628-3186525 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9004.31 Da        Isoelectric Point: 7.2042

>AT236293 WP_000535213.1 NZ_CP092493:c4343589-4343341 [Citrobacter freundii]
MGSLTKQTISAQIPVELAAAVENLAIELDRSKSWIIKEALTSMLAERERRHQSIQAGLADVDAGRVVSHSDMVDFANRLK
KS

Download         Length: 249 bp

>AT236293 NZ_LR217818:3186487-3186758 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References