Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2499838..2500477 Replicon chromosome
Accession NZ_CP092493
Organism Citrobacter freundii strain SCLZS47

Toxin (Protein)


Gene name hicA Uniprot ID A0A8B5QF36
Locus tag MJ253_RS12335 Protein ID WP_003020221.1
Coordinates 2499838..2500014 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag MJ253_RS12340 Protein ID WP_123924900.1
Coordinates 2500061..2500477 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJ253_RS12315 (2496616) 2496616..2496846 - 231 WP_003020233.1 DUF2554 family protein -
MJ253_RS12320 (2497036) 2497036..2497161 - 126 WP_003020230.1 DUF2474 domain-containing protein -
MJ253_RS12325 (2497161) 2497161..2498171 - 1011 WP_003020227.1 cytochrome d ubiquinol oxidase subunit II -
MJ253_RS12330 (2498171) 2498171..2499574 - 1404 WP_003020224.1 cytochrome ubiquinol oxidase subunit I -
MJ253_RS12335 (2499838) 2499838..2500014 + 177 WP_003020221.1 type II toxin-antitoxin system HicA family toxin Toxin
MJ253_RS12340 (2500061) 2500061..2500477 + 417 WP_123924900.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MJ253_RS12345 (2500570) 2500570..2501979 + 1410 WP_134215520.1 PLP-dependent aminotransferase family protein -
MJ253_RS12350 (2502308) 2502308..2503453 + 1146 WP_134215522.1 ABC transporter substrate-binding protein -
MJ253_RS12355 (2503470) 2503470..2504486 + 1017 WP_058842662.1 ABC transporter ATP-binding protein -
MJ253_RS12360 (2504487) 2504487..2505431 + 945 WP_003843727.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6769.80 Da        Isoelectric Point: 11.2510

>T236290 WP_003020221.1 NZ_CP092493:2499838-2500014 [Citrobacter freundii]
VKQSEFRRWLESQGVAVTNGSNHLKLRYQGRRSVMPRHPGDEIKEALRKAIIKQLDLQ

Download         Length: 177 bp

>T236290 NZ_LR217818:c2512896-2512789 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15126.36 Da        Isoelectric Point: 4.5716

>AT236290 WP_123924900.1 NZ_CP092493:2500061-2500477 [Citrobacter freundii]
MRYPVTLTPAVEGGFVVSFPDIPEALTQGNTRHDALQAAQAALITAFEFYFDDNEAIPLPSAVSAEDDYVEIPLSVASKV
LLLNAFLESKITQQELANRIGRPKQEITRLFDLKHTTKIDAVQIAARALGKELALTML

Download         Length: 417 bp

>AT236290 NZ_LR217818:2512943-2513009 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B5QF36

Antitoxin

Source ID Structure

References