Detailed information of TA system TA236275

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 2944997..2945997
• Replicon: chromosome
• Accession: NZ_CP092488
• Organism: Mycobacterium paraterrae strain DSM 45127

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: MKK62_RS14090
• Protein ID: WP_240260313.1
• Coordinates: 2944997..2945575 (-)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: MKK62_RS14095
• Protein ID: WP_240260312.1
• Coordinates: 2945572..2945997 (-)
• Length: 142 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKK62_RS14070 (MKK62_20590)	2941527..2942354	-	828	WP_240260317.1	alpha/beta hydrolase	-
MKK62_RS14075 (MKK62_20585)	2942467..2943672	+	1206	WP_240260316.1	PucR family transcriptional regulator	-
MKK62_RS14080 (MKK62_20580)	2943794..2944324	+	531	WP_240260315.1	hypothetical protein	-
MKK62_RS14085 (MKK62_20575)	2944452..2944946	-	495	WP_240260314.1	barstar family protein	-
MKK62_RS14090 (MKK62_20570)	2944997..2945575	-	579	WP_240260313.1	zeta toxin family protein	Toxin
MKK62_RS14095 (MKK62_20565)	2945572..2945997	-	426	WP_240260312.1	ParD-like family protein	Antitoxin
MKK62_RS14100 (MKK62_20560)	2946057..2946446	-	390	WP_240260311.1	hypothetical protein	-
MKK62_RS14105 (MKK62_20555)	2946492..2946749	-	258	WP_240260310.1	hypothetical protein	-
MKK62_RS14110 (MKK62_20550)	2946749..2947846	-	1098	WP_240260309.1	hypothetical protein	-
MKK62_RS14115 (MKK62_20545)	2947850..2948128	-	279	WP_240260307.1	hypothetical protein	-
MKK62_RS14120 (MKK62_20540)	2948221..2948988	+	768	WP_240260306.1	class I SAM-dependent methyltransferase	-
MKK62_RS14125 (MKK62_20535)	2949077..2950036	+	960	WP_240260304.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-137)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 20913.04 Da
• Isoelectric Point: 8.9047

>T236275 WP_240260313.1 NZ_CP092488:c2945575-2944997 [Mycobacterium paraterrae]
MKRLDLVVGPNGAGKSTFVELTLAPLLPGSPFVNADEIAKQRWPDDPAAHSYDAARVAAATRTKLIELGVSFIAETVFSH
PSKVELVDAARAAHYTIVLHVLIIPEELAVERVRHRVAAGGHSVPEDKIRERYQRLWGFVAVAMTRSDSATVYDSSGIKG
PRIVAQINDGFLVGSPAWPRWTPAVLREVCKA

Nucleotide

• Length: 579 bp

>T236275 NZ_LR217818:c639220-638756 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGTTCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin

Protein

• Length: 142 a.a.
• Molecular weight: 15136.98 Da
• Isoelectric Point: 8.6766

>AT236275 WP_240260312.1 NZ_CP092488:c2945997-2945572 [Mycobacterium paraterrae]
MTNIADRVTRVAADLMDSAAAEGARQSRSAKQQLDHWARVGRAVSTQQTAARRRVEAALAGELELRELSVEEGVVLNAEI
AASIQENLAASDYGKVLAARGITTVALDDEGDIVEHRPDGSSIVLSANQPRRRKAKPAPKR

Nucleotide

• Length: 426 bp

>AT236275 NZ_LR217818:c639555-639220 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA