Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2932120..2932769 Replicon chromosome
Accession NZ_CP092488
Organism Mycobacterium paraterrae strain DSM 45127

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MKK62_RS14030 Protein ID WP_240260356.1
Coordinates 2932362..2932769 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MKK62_RS14025 Protein ID WP_240260358.1
Coordinates 2932120..2932365 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKK62_RS14010 (MKK62_20650) 2928362..2928748 - 387 WP_240260362.1 very short patch repair endonuclease -
MKK62_RS14015 (MKK62_20645) 2928947..2929960 + 1014 WP_240260361.1 DNA (cytosine-5-)-methyltransferase -
MKK62_RS14020 (MKK62_20640) 2929921..2931099 - 1179 WP_260060431.1 HNH endonuclease -
MKK62_RS14025 (MKK62_20635) 2932120..2932365 + 246 WP_240260358.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MKK62_RS14030 (MKK62_20630) 2932362..2932769 + 408 WP_240260356.1 type II toxin-antitoxin system VapC family toxin Toxin
MKK62_RS14035 (MKK62_20625) 2932894..2933772 + 879 WP_240260354.1 alpha/beta fold hydrolase -
MKK62_RS14040 (MKK62_20620) 2933802..2934317 + 516 WP_240260347.1 nitroreductase family protein -
MKK62_RS14045 (MKK62_20615) 2934337..2935356 - 1020 WP_240260342.1 type VII secretion-associated serine protease mycosin -
MKK62_RS14050 (MKK62_20610) 2935842..2937131 - 1290 WP_240260335.1 cytochrome P450 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-123)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14607.51 Da        Isoelectric Point: 4.6254

>T236274 WP_240260356.1 NZ_CP092488:2932362-2932769 [Mycobacterium paraterrae]
VIVDTSAIIAILRQEDDAGIFAQVIAHADTRRLSAASYLECGIVLDFQRDPIVSRALDALVEEAGFVIEPVTEHQARLAR
QAYADFGKGRHVAGLNFGDCLAYALALDRREPLLWKGDDFGHTGVESALVKEAGS

Download         Length: 408 bp

>T236274 NZ_LR216065:c1621317-1621138 [Streptococcus pneumoniae]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAAAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTAAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8763.11 Da        Isoelectric Point: 8.6991

>AT236274 WP_240260358.1 NZ_CP092488:2932120-2932365 [Mycobacterium paraterrae]
MALNIKDVSVHEVVKQIAKLTGESQAQAVATAVRERLARLQGDDLAARLLAIGHKTASRMSPETKMLDHDTLLYDGRGLP
A

Download         Length: 246 bp

>AT236274 NZ_LR216065:c1621101-1620649 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References