Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 2622733..2623304 Replicon chromosome
Accession NZ_CP092488
Organism Mycobacterium paraterrae strain DSM 45127

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag MKK62_RS12555 Protein ID WP_240260771.1
Coordinates 2622733..2623110 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag MKK62_RS12560 Protein ID WP_240260770.1
Coordinates 2623107..2623304 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKK62_RS12535 (MKK62_22120) 2618480..2618986 + 507 WP_240260775.1 GNAT family N-acetyltransferase -
MKK62_RS12540 (MKK62_22115) 2618983..2620092 + 1110 WP_240260774.1 LLM class flavin-dependent oxidoreductase -
MKK62_RS12545 (MKK62_22110) 2620089..2621210 + 1122 WP_240260773.1 LLM class flavin-dependent oxidoreductase -
MKK62_RS12550 (MKK62_22105) 2621207..2622553 + 1347 WP_240260772.1 NtaA/DmoA family FMN-dependent monooxygenase -
MKK62_RS12555 (MKK62_22100) 2622733..2623110 - 378 WP_240260771.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
MKK62_RS12560 (MKK62_22095) 2623107..2623304 - 198 WP_240260770.1 antitoxin Phd Antitoxin
MKK62_RS12565 (MKK62_22090) 2623445..2623834 - 390 WP_240260769.1 heme-binding protein -
MKK62_RS12570 (MKK62_22085) 2624063..2624803 - 741 WP_240260768.1 MBL fold metallo-hydrolase -
MKK62_RS12575 (MKK62_22080) 2624860..2625870 + 1011 WP_240260767.1 glucose-6-phosphate dehydrogenase (coenzyme-F420) -
MKK62_RS12580 (MKK62_22075) 2625879..2627999 + 2121 WP_240260766.1 phosphate acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(26-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13391.09 Da        Isoelectric Point: 4.1155

>T236273 WP_240260771.1 NZ_CP092488:c2623110-2622733 [Mycobacterium paraterrae]
VIFYLERDDVVVGGSIACGFSLAVSDEGLLQSAVARPQTSVMGDDAYPTLWDKAAALLHSLARNYAFVDGNKRTAWASAW
AFLRLNGIDLPDAYDVDYAEQLVLTAAVGDVDWPKIADGLRALAG

Download         Length: 378 bp

>T236273 NZ_LR216065:c1575103-1574849 [Streptococcus pneumoniae]
ATGCTGCTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTACTGGCAAAATCAGGATAAGAAAACGTTAAAAAGAAT
CAATAAACTAATCAAGGATATTCAACGTGATCCCTTTACAGGAATAGGTAAACCAGAACCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7102.05 Da        Isoelectric Point: 10.7950

>AT236273 WP_240260770.1 NZ_CP092488:c2623304-2623107 [Mycobacterium paraterrae]
VPALNIQFTDDELARVRTAASRNGKALKPFARDAILAAADARAARVTEAFEYVTARSTELNRRLA

Download         Length: 198 bp

>AT236273 NZ_LR216065:c1575361-1575107 [Streptococcus pneumoniae]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTCCTTTCAAAGAGTGAGTGGGATAGTATCCAAGAAACCCTGA
GAATTGCTCAAAATAAGGAACTTTCTGATAAGGTTTTGCGAGGAATGGCTCAAGTTCGTGCTGGAAGTACTCAGGTCCAT
GTTATTGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References