Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 849041..849664 Replicon chromosome
Accession NZ_CP092488
Organism Mycobacterium paraterrae strain DSM 45127

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag MKK62_RS03930 Protein ID WP_240262319.1
Coordinates 849041..849478 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID -
Locus tag MKK62_RS03935 Protein ID WP_240263833.1
Coordinates 849491..849664 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKK62_RS03910 (MKK62_04350) 845005..846219 + 1215 WP_240262323.1 acetyl-CoA acetyltransferase -
MKK62_RS03915 (MKK62_04345) 846219..847709 + 1491 WP_240262322.1 carotenoid oxygenase family protein -
MKK62_RS03920 (MKK62_04340) 847699..848601 + 903 WP_240262321.1 winged helix-turn-helix transcriptional regulator -
MKK62_RS03925 (MKK62_04335) 848598..849014 - 417 WP_240262320.1 hypothetical protein -
MKK62_RS03930 (MKK62_04330) 849041..849478 - 438 WP_240262319.1 SRPBCC family protein Toxin
MKK62_RS03935 (MKK62_04325) 849491..849664 - 174 WP_240263833.1 antitoxin Antitoxin
MKK62_RS03940 (MKK62_04320) 849687..850811 - 1125 WP_240262318.1 MBL fold metallo-hydrolase -
MKK62_RS03945 (MKK62_04315) 850816..851547 - 732 WP_240262317.1 enoyl-CoA hydratase -
MKK62_RS03950 (MKK62_04310) 851705..853306 + 1602 WP_240262316.1 arylsulfatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-52)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15718.37 Da        Isoelectric Point: 9.9747

>T236272 WP_240262319.1 NZ_CP092488:c849478-849041 [Mycobacterium paraterrae]
MAKLSGSIDVPLSPEQAWEAASDLSRFKEWLTIHRVWRSKLPDTLEKGTVIESIVEVKGMPNRISWTIVHYKPPESMTLN
GVGVGGVKVKLLAKVKPNGDQSVVSFDVHLGGPALFGPIGMIVAAALKTDINESLRKFVTVFAPA

Download         Length: 438 bp

>T236272 NZ_LR216065:c1103668-1103414 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTCATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAATCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6027.67 Da        Isoelectric Point: 4.2985

>AT236272 WP_240263833.1 NZ_CP092488:c849664-849491 [Mycobacterium paraterrae]
MGFLDKAKDLLAQNADTVNSAIEKAGDFVDEKTDGKFAGVVDQAQEAAKNALKDKGE

Download         Length: 174 bp

>AT236272 NZ_LR216065:c1103912-1103670 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References