Detailed information of TA system TA236271

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 364371..365074
• Replicon: chromosome
• Accession: NZ_CP092488
• Organism: Mycobacterium paraterrae strain DSM 45127

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MKK62_RS01630
• Protein ID: WP_240262707.1
• Coordinates: 364371..364823 (-)
• Length: 151 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MKK62_RS01635
• Protein ID: WP_240262706.1
• Coordinates: 364820..365074 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKK62_RS01615 (MKK62_06640)	359720..361453	-	1734	WP_240262710.1	hypothetical protein	-
MKK62_RS01620 (MKK62_06635)	361738..363459	-	1722	WP_240262709.1	hypothetical protein	-
MKK62_RS01625 (MKK62_06630)	363650..364378	-	729	WP_240262708.1	nitroreductase family protein	-
MKK62_RS01630 (MKK62_06625)	364371..364823	-	453	WP_240262707.1	type II toxin-antitoxin system VapC family toxin	Toxin
MKK62_RS01635 (MKK62_06620)	364820..365074	-	255	WP_240262706.1	antitoxin	Antitoxin
MKK62_RS01640 (MKK62_06615)	365124..365624	-	501	WP_240262705.1	DUF2505 domain-containing protein	-
MKK62_RS01645 (MKK62_06610)	365632..366339	-	708	WP_240262704.1	flavodoxin family protein	-
MKK62_RS01650 (MKK62_06605)	366382..367212	+	831	WP_240262703.1	class I SAM-dependent methyltransferase	-
MKK62_RS01655 (MKK62_06600)	367205..368458	-	1254	WP_240262702.1	condensation domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-134)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 151 a.a.
• Molecular weight: 16078.05 Da
• Isoelectric Point: 5.4395

>T236271 WP_240262707.1 NZ_CP092488:c364823-364371 [Mycobacterium paraterrae]
MRIVDANVLLYAVNTAADHHEASRRWLDGALSGGDTVGLAWVPLLAFVRLTTRHGLFPSPLTTEAAMTQVLDWCSAPGSV
IVSPSPRHGDVLSGLLSQVGAGGNLVNDAHLAALAIEHRARIVSYDSDFGRFDGVQWETPGSLLERNDHD

Nucleotide

• Length: 453 bp

>T236271 NZ_LR216065:956463-957224 [Streptococcus pneumoniae]
ATGGAAATCCAAGATTATACTGATAGTGAATTCAAACATGCTTTAGCAAGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAACAACCTATAGCGATTTTGCTTGGAGGTCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGTGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCAA
GAATATGGCAAAGACAGTGTAGAATATACCAAAGATTTTGCAGGAAAAATGGTAGAGTCTTTAGTAACAAAATTGAGTAG
TTTGAGATACAATCTTTTGATAGAGGGAACTTTACGAACAGTTGATGTTCCAAAGAAAACAGCACAACTCTTGAAAAATA
AGGGATATGAAGTACAATTGGCCTTAATTGCGACAAAGCCTGAATTGTCGTATCTAAGTACTCTTATCCGTTATGAAGAA
CTGTACATTATCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
TACACGACAATTGGAAGAACTGGCTATCTTTGAAAGAATTCAAATTTACCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATACAACTTCAGCAGCAGATGTTCTTCAAGAGTTACTGTTTGGGGAGTGGAGTCAGGTAGAGAAGGAGATGTTG
CAGGTGGGGGAAAAGAGACTTAATGAATTACTTGAAAAATAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9509.78 Da
• Isoelectric Point: 7.0150

>AT236271 WP_240262706.1 NZ_CP092488:c365074-364820 [Mycobacterium paraterrae]
VRTTVTLDDDTLVVVKRLMREHNVSFKQALNDAIRRGAQRQPAQVVFETQTADLGVPSINLDRALQLAGELEDEELIRRQ
RRGA

Nucleotide

• Length: 255 bp

>AT236271 NZ_LR216065:955987-956463 [Streptococcus pneumoniae]
ATGATTGGAAAGAACATAAAATCCTTACGTAAAACACATGACTTAACACAACCTGAATTTGCACGAATTATAGGAATTTC
TCGAAATAGCTTGAGTCGTTATGAAAATGGAACTAGTTCAGTCTCTACGGAATTAATTGACATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGATTATGAATTGACTTTGAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTATTATCTCGACTCTATCGTTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGACTTGATTCAGACAAATATCTATTTAGTAGAAAATTTTGATG
AAATAGAGAGATATAGCGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAGCGGATGGTAGCTTAA