Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 2012380..2012848 | Replicon | chromosome |
| Accession | NZ_CP092478 | ||
| Organism | Staphylococcus haemolyticus strain CGMH-SH51 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | Q4L4Q4 |
| Locus tag | MKD39_RS09800 | Protein ID | WP_011276326.1 |
| Coordinates | 2012660..2012848 (+) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | Q4L4Q5 |
| Locus tag | MKD39_RS09795 | Protein ID | WP_011276325.1 |
| Coordinates | 2012380..2012637 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MKD39_RS09760 (MKD39_09750) | 2007556..2008281 | - | 726 | WP_011276319.1 | type I 3-dehydroquinate dehydratase | - |
| MKD39_RS09765 (MKD39_09755) | 2008444..2008866 | + | 423 | WP_011276320.1 | organic hydroperoxide resistance protein | - |
| MKD39_RS09770 (MKD39_09760) | 2009129..2009620 | + | 492 | WP_033079649.1 | GNAT family N-acetyltransferase | - |
| MKD39_RS09775 (MKD39_09765) | 2009752..2010369 | + | 618 | WP_046309566.1 | LysE/ArgO family amino acid transporter | - |
| MKD39_RS09780 (MKD39_09770) | 2010556..2011164 | - | 609 | WP_011276323.1 | histidine phosphatase family protein | - |
| MKD39_RS09785 (MKD39_09775) | 2011392..2011634 | + | 243 | WP_011276324.1 | hypothetical protein | - |
| MKD39_RS09790 (MKD39_09780) | 2011626..2011829 | - | 204 | WP_033079647.1 | sterile alpha motif-like domain-containing protein | - |
| MKD39_RS09795 (MKD39_09785) | 2012380..2012637 | + | 258 | WP_011276325.1 | hypothetical protein | Antitoxin |
| MKD39_RS09800 (MKD39_09790) | 2012660..2012848 | + | 189 | WP_011276326.1 | hypothetical protein | Toxin |
| MKD39_RS09805 (MKD39_09795) | 2012966..2013547 | + | 582 | WP_011276327.1 | lipoprotein N-acylation protein LnsA | - |
| MKD39_RS09810 (MKD39_09800) | 2013595..2013831 | - | 237 | WP_016931008.1 | hypothetical protein | - |
| MKD39_RS09815 (MKD39_09805) | 2014001..2014747 | + | 747 | WP_033079645.1 | membrane lipoprotein lipid attachment site-containing protein | - |
| MKD39_RS09820 (MKD39_09810) | 2014816..2015424 | - | 609 | WP_033079644.1 | GNAT family N-acetyltransferase | - |
| MKD39_RS09825 (MKD39_09815) | 2015561..2016307 | + | 747 | WP_033079643.1 | poly-gamma-glutamate hydrolase family protein | - |
| MKD39_RS09830 (MKD39_09820) | 2016383..2016670 | + | 288 | WP_033079642.1 | hypothetical protein | - |
| MKD39_RS09835 (MKD39_09825) | 2016914..2017138 | + | 225 | WP_033079641.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | fusB | - | 2011392..2040830 | 29438 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7110.80 Da Isoelectric Point: 9.6269
>T236266 WP_011276326.1 NZ_CP092478:2012660-2012848 [Staphylococcus haemolyticus]
MSLHLTILLWLGIIFVIAASIILGLLLKSKKEERKESYLGFTVIFYIFGFALLIYVFIFGIL
MSLHLTILLWLGIIFVIAASIILGLLLKSKKEERKESYLGFTVIFYIFGFALLIYVFIFGIL
Download Length: 189 bp
>T236266 NZ_LR216060:c1160406-1160152 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGGTCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGGTCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9914.97 Da Isoelectric Point: 4.0625
>AT236266 WP_011276325.1 NZ_CP092478:2012380-2012637 [Staphylococcus haemolyticus]
MNNNKIFWINIFMTLLFLGFNIIVTYNADLDDFFWLIPGLTISGITIVLSLSTALICKNLVSEVIFLINIVMLLYYIYPM
VYTFF
MNNNKIFWINIFMTLLFLGFNIIVTYNADLDDFFWLIPGLTISGITIVLSLSTALICKNLVSEVIFLINIVMLLYYIYPM
VYTFF
Download Length: 258 bp
>AT236266 NZ_LR216060:c1160650-1160408 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2A1KAB5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2A1KAX9 |