Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 886220..886752 Replicon chromosome
Accession NZ_CP092478
Organism Staphylococcus haemolyticus strain CGMH-SH51

Toxin (Protein)


Gene name mazF Uniprot ID Q4L7V3
Locus tag MKD39_RS04285 Protein ID WP_011275272.1
Coordinates 886387..886752 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q4L7V4
Locus tag MKD39_RS04280 Protein ID WP_011275271.1
Coordinates 886220..886390 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKD39_RS04255 (MKD39_04250) 882006..882485 + 480 WP_011275266.1 PH domain-containing protein -
MKD39_RS04260 (MKD39_04255) 882478..884001 + 1524 WP_016931363.1 PH domain-containing protein -
MKD39_RS04265 (MKD39_04260) 883994..884521 + 528 WP_033080076.1 PH domain-containing protein -
MKD39_RS04270 (MKD39_04265) 884531..884890 + 360 WP_011275269.1 holo-ACP synthase -
MKD39_RS04275 (MKD39_04270) 884986..886134 + 1149 WP_016931365.1 alanine racemase -
MKD39_RS04280 (MKD39_04275) 886220..886390 + 171 WP_011275271.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MKD39_RS04285 (MKD39_04280) 886387..886752 + 366 WP_011275272.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MKD39_RS04290 (MKD39_04285) 887060..888061 + 1002 WP_011275273.1 PP2C family protein-serine/threonine phosphatase -
MKD39_RS04295 (MKD39_04290) 888160..888486 + 327 WP_011275274.1 anti-sigma factor antagonist -
MKD39_RS04300 (MKD39_04295) 888515..888967 + 453 WP_046309853.1 anti-sigma B factor RsbW -
MKD39_RS04305 (MKD39_04300) 888942..889712 + 771 WP_011275276.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13672.75 Da        Isoelectric Point: 8.4121

>T236264 WP_011275272.1 NZ_CP092478:886387-886752 [Staphylococcus haemolyticus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYRLDKDSVILLEQIR
TLDKKRLKEKLTYLSDEKMQEVDEALDISLGLHDEVKTQNT

Download         Length: 366 bp

>T236264 NZ_LR216050:c1609116-1608937 [Streptococcus pneumoniae]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAAAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6380.08 Da        Isoelectric Point: 4.0325

>AT236264 WP_011275271.1 NZ_CP092478:886220-886390 [Staphylococcus haemolyticus]
MLTFNQNRSHSLEQSLKEGYAQMAELNLSLATEAFPLECEACDCNETYLISNYKSE

Download         Length: 171 bp

>AT236264 NZ_LR216050:c1608900-1608448 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A1KA75

Antitoxin

Source ID Structure
AlphaFold DB A0A2A1K7K7

References