Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) TsdAT/-
Location 873295..873806 Replicon chromosome
Accession NZ_CP092478
Organism Staphylococcus haemolyticus strain CGMH-SH51

Toxin (Protein)


Gene name TsdT Uniprot ID Q4L7W7
Locus tag MKD39_RS04220 Protein ID WP_011275259.1
Coordinates 873600..873806 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag MKD39_RS04215 Protein ID WP_011275258.1
Coordinates 873295..873588 (+) Length 98 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKD39_RS04195 (MKD39_04190) 868450..869325 + 876 WP_011275255.1 membrane protein insertase YidC -
MKD39_RS04200 (MKD39_04195) 869520..870836 + 1317 WP_152235232.1 ISL3 family transposase -
MKD39_RS04205 (MKD39_04200) 870883..871524 - 642 WP_016931420.1 HD domain-containing protein -
MKD39_RS04210 (MKD39_04205) 871624..873108 - 1485 WP_011275257.1 cardiolipin synthase -
MKD39_RS04215 (MKD39_04210) 873295..873588 + 294 WP_011275258.1 copper-sensing transcriptional repressor CsoR Antitoxin
MKD39_RS04220 (MKD39_04215) 873600..873806 + 207 WP_011275259.1 heavy-metal-associated domain-containing protein Toxin
MKD39_RS04225 (MKD39_04220) 873914..874051 + 138 WP_011275260.1 Lmo0850 family protein -
MKD39_RS04230 (MKD39_04225) 874348..876025 + 1678 Protein_833 IS1182 family transposase -
MKD39_RS04235 (MKD39_04230) 876000..877199 - 1200 WP_011275262.1 FtsW/RodA/SpoVE family cell cycle protein -
MKD39_RS04240 (MKD39_04235) 877617..878687 + 1071 WP_011275263.1 D-alanine--D-alanine ligase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 869520..876042 6522


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(3-95)


Sequences


Toxin        


Download         Length: 69 a.a.        Molecular weight: 7857.79 Da        Isoelectric Point: 4.0742

>T236263 WP_011275259.1 NZ_CP092478:873600-873806 [Staphylococcus haemolyticus]
MNFSEIRISELNTEEQANSLQHRLEKMIGVDEVIVELNDQLVKISYETPTNLNSIEKEIYDDGYKVLG

Download         Length: 207 bp

>T236263 NZ_LR216050:c1584631-1584377 [Streptococcus pneumoniae]
ATGCTGCTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTACTGGCAAAATCAGGATAAGAAAACGTTAAAAAGAAT
CAATAAACTAATCAAGGATATTCAACGTGATCCCTTTACAGGAATAGGTAAACCAGAACCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11222.83 Da        Isoelectric Point: 6.6361

>AT236263 WP_011275258.1 NZ_CP092478:873295-873588 [Staphylococcus haemolyticus]
MNNHENAHHSDQIKMNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVNNGAQ
EEAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT236263 NZ_LR216050:c1584889-1584635 [Streptococcus pneumoniae]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTCCTTTCAAAGAGTGAGTGGGATAGTATCCAAGAAACCCTGA
GAATTGCTCAAAATAAGGAACTTTCTGATAAGGTTTTGCGAGGAATGGCTCAAGTTCGTGCTGGAAGTACTCAGGTCCAT
GTTATTGAGGAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2A1K7I8


Antitoxin

Source ID Structure

References