Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1996414..1996891 Replicon chromosome
Accession NZ_CP092475
Organism Staphylococcus aureus strain P5

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag MKD48_RS10205 Protein ID WP_000052076.1
Coordinates 1996703..1996891 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag MKD48_RS10200 Protein ID WP_001059690.1
Coordinates 1996414..1996674 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKD48_RS10165 (1991810) 1991810..1992526 - 717 WP_000150015.1 type I 3-dehydroquinate dehydratase -
MKD48_RS10170 (1992674) 1992674..1993096 + 423 WP_000974455.1 organic hydroperoxide resistance protein -
MKD48_RS10175 (1993495) 1993495..1993989 + 495 WP_000590539.1 GNAT family N-acetyltransferase -
MKD48_RS10180 (1994142) 1994142..1994759 + 618 WP_000255559.1 LysE/ArgO family amino acid transporter -
MKD48_RS10185 (1994832) 1994832..1995413 - 582 WP_001140696.1 histidine phosphatase family protein -
MKD48_RS10190 (1995638) 1995638..1995874 + 237 WP_000368687.1 hypothetical protein -
MKD48_RS10195 (1995871) 1995871..1996074 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
MKD48_RS10200 (1996414) 1996414..1996674 + 261 WP_001059690.1 hypothetical protein Antitoxin
MKD48_RS10205 (1996703) 1996703..1996891 + 189 WP_000052076.1 hypothetical protein Toxin
MKD48_RS10210 (1997079) 1997079..1997648 + 570 WP_001106646.1 lipoprotein N-acylation protein LnsA -
MKD48_RS10215 (1997736) 1997736..1998020 + 285 WP_001004395.1 hypothetical protein -
MKD48_RS10220 (1998082) 1998082..1998300 + 219 WP_000005876.1 hypothetical protein -
MKD48_RS10225 (1998796) 1998796..1998996 - 201 WP_001059082.1 cold-shock protein -
MKD48_RS10230 (1999353) 1999353..2000039 - 687 WP_001670297.1 thermonuclease family protein -
MKD48_RS10235 (2000380) 2000380..2000901 - 522 WP_000824488.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-72)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T236262 WP_000052076.1 NZ_CP092475:1996703-1996891 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T236262 NZ_LR216050:c1131486-1131232 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT236262 WP_001059690.1 NZ_CP092475:1996414-1996674 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT236262 NZ_LR216050:c1131730-1131488 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATCCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References