Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2338312..2339007 Replicon chromosome
Accession NC_012207
Organism Mycobacterium bovis BCG str. Tokyo 172

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag JTY_RS10890 Protein ID WP_003410811.1
Coordinates 2338312..2338746 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag JTY_RS10895 Protein ID WP_003410814.1
Coordinates 2338753..2339007 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JTY_RS10880 2334466..2337507 + 3042 WP_010950658.1 DEAD/DEAH box helicase -
JTY_RS10885 2337500..2338333 + 834 WP_003899172.1 SWIM zinc finger family protein -
JTY_RS10890 2338312..2338746 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
JTY_RS10895 2338753..2339007 - 255 WP_003410814.1 antitoxin Antitoxin
JTY_RS10900 2339023..2339280 - 258 WP_003410816.1 hypothetical protein -
JTY_RS10905 2340227..2340523 + 297 WP_003410820.1 PE family protein -
JTY_RS10910 2340579..2341310 + 732 WP_003900467.1 PPE family protein -
JTY_RS10915 2341850..2342596 - 747 WP_003901330.1 proteasome subunit alpha -
JTY_RS10920 2342593..2343468 - 876 WP_003411023.1 proteasome subunit beta -
JTY_RS10925 2343465..2343659 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T23626 WP_003410811.1 NC_012207:c2338746-2338312 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T23626 NC_012207:c2338746-2338312 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT23626 WP_003410814.1 NC_012207:c2339007-2338753 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT23626 NC_012207:c2339007-2338753 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References