Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 681134..681663 Replicon chromosome
Accession NZ_CP092475
Organism Staphylococcus aureus strain P5

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MKD48_RS03410 Protein ID WP_000621175.1
Coordinates 681301..681663 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MKD48_RS03405 Protein ID WP_000948330.1
Coordinates 681134..681304 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKD48_RS03375 (676170) 676170..676730 + 561 WP_001092400.1 K(+)-transporting ATPase subunit C -
MKD48_RS03380 (676939) 676939..677418 + 480 WP_001287080.1 hypothetical protein -
MKD48_RS03385 (677411) 677411..678994 + 1584 WP_001294624.1 PH domain-containing protein -
MKD48_RS03390 (678981) 678981..679472 + 492 WP_001205918.1 PH domain-containing protein -
MKD48_RS03395 (679476) 679476..679835 + 360 WP_000581193.1 holo-ACP synthase -
MKD48_RS03400 (679901) 679901..681049 + 1149 WP_001281141.1 alanine racemase -
MKD48_RS03405 (681134) 681134..681304 + 171 WP_000948330.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MKD48_RS03410 (681301) 681301..681663 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MKD48_RS03415 (682012) 682012..683013 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
MKD48_RS03420 (683133) 683133..683459 + 327 WP_001052491.1 anti-sigma factor antagonist -
MKD48_RS03425 (683461) 683461..683940 + 480 WP_001190825.1 anti-sigma B factor RsbW -
MKD48_RS03430 (683915) 683915..684685 + 771 WP_001041107.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T236249 WP_000621175.1 NZ_CP092475:681301-681663 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T236249 NZ_LR215729:1707121-1707690 [Pseudomonas marincola]
ATGTTCAAACCCCAGTTGATTACCCTGCAACGCGGCGCATTGCGGATTGAGCCGATGATGGACGCGGACATTCCGGCGCT
GGTGTCGCTCGCCGAAGCCAACCGCAATGAACTCATTTATATGGGCGGCGCACAACGTCTGGACTGGTATCGGCAGGGCA
TCGTCGAGCAGCAGAACAGCCGCGCGCTGCCGTTCACCATTCGCCTGGGCACTGAAATAGTCGGCACCACGCGCTACGCC
GACTTTATGCCGACGCTGCCCGCGTGTGAGATCGGCTGGACGTGGCTGGATAAAGGCCAGCATGGCACCGGCTTGAACAG
CATGATCAAATACCTGATGCTGCGCCACGCGTTCGAGGGCTGGCGCATGGTGCGTGTGCAGTTGAAAACCGCTGCCAGTA
ATTTGCGCGCACAAGCTGCCATCGAGAAAATCGGTGCGCAGCGCGAAGGCATTTTGCGTAATCATCGCCGACTGTCTGAA
GGCCGGCTGGATGACAGCGTGCTGTACAGCATTACTGATCAGGAGTGGCCAGCGGTGAAGAAAATGATCGAGTCAGGATT
CGGCGGTTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6237.75 Da        Isoelectric Point: 3.8305

>AT236249 WP_000948330.1 NZ_CP092475:681134-681304 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNESYLSSNSTNE

Download         Length: 171 bp

>AT236249 NZ_LR215729:1707698-1708537 [Pseudomonas marincola]
ATGAACGAGGCGCTGGAGCAAACCCGGTTTTGGCAGGCCAAGGGCCTGGCTGATGTTGAACTTTTGCACGCACGGTATGT
GCAGCAGCGGTTTGCGCCGCATGTTCATGAGGGTTTTGTGTTTACCGTTATCCAGAACGGCGCACAGCGCTTCCGTCATC
GCGGCAGTGATCACCTGGCCCCGCAAGGCAGCATGGTGCTGATCAATCCCGACGAAGTTCATACCGGCTCCAAAGCGCAT
GACGATGGCTGGCGCTACCGCGCTTTTTATCCCGACAACCGCCAGGTACAGGGCGTACTGCAAGAGCTTGATCTGGCGGG
ATCAGGGCTGCCTGGCTTTGCGCTAAGCGTGCTGCACGACCCGCAACTGCATGCTGCTTTCACCGGCTTGCATCAGTTGC
TTGAAGGCGGTGCCGATGCCTTGCAGCAGCAGATTGTCTGGCGTGAGGCTATCTTGTTGCTGTTTCAACGCTACGCCAAG
GTCGCCGAACCCGCTGCGCCCGGCCGTGAAGCCCGTGCGGTCGAGCTGGCCAAGGAGTTGCTTAACAGTCAGTTAGCCGC
GCCGCCGTCGCTTGAAGAGCTGGCCACTGCAGTGAATCTCTCGCCGTTTCACTTTGCCCGGGTCTTTCGCCGAGCAACGG
GTTTGCCCCCTCATGCATGGCTCAAGCAGCGGCGATTGGCGCAGGCGCGGGCATTGCTCAAGCAAGGTTGCATGCCGGCG
CAGGTGGCCATGCAGCTCGGTTTCTCTGATCAGAGCCATCTGAGTCGTCAGTTCAAGCAGGTGTACGGCGTGGGGCCGGG
CGCTTACCGCAATGCCAGCGCCGGAATAGCCTCGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References