Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 661393..661907 Replicon chromosome
Accession NZ_CP092475
Organism Staphylococcus aureus strain P5

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag MKD48_RS03320 Protein ID WP_000581792.1
Coordinates 661698..661907 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag MKD48_RS03315 Protein ID WP_000138928.1
Coordinates 661393..661686 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKD48_RS03295 (656991) 656991..657632 + 642 WP_000483153.1 thiamine phosphate synthase -
MKD48_RS03300 (657718) 657718..658590 + 873 WP_000725802.1 membrane protein insertase YidC -
MKD48_RS03305 (659068) 659068..659715 - 648 WP_001187617.1 HD domain-containing protein -
MKD48_RS03310 (659743) 659743..661227 - 1485 WP_000571551.1 cardiolipin synthase -
MKD48_RS03315 (661393) 661393..661686 + 294 WP_000138928.1 copper-sensing transcriptional repressor CsoR Antitoxin
MKD48_RS03320 (661698) 661698..661907 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
MKD48_RS03325 (662035) 662035..662172 + 138 WP_000828354.1 Lmo0850 family protein -
MKD48_RS03330 (662436) 662436..663638 - 1203 WP_248313613.1 FtsW/RodA/SpoVE family cell cycle protein -
MKD48_RS03335 (663956) 663956..665026 + 1071 WP_000159632.1 D-alanine--D-alanine ligase -
MKD48_RS03340 (665041) 665041..666399 + 1359 WP_000611469.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T236248 WP_000581792.1 NZ_CP092475:661698-661907 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T236248 NZ_LR214441:c2142137-2141871 [Tessaracoccus lapidicaptus]
GTGAACTCCTGGACTCTGGTGTACTCGCGCCAGGCCCAGAAGGACGCCAAGAAGCTGGCCTCCCCGGGGCTGAAGACGAA
GGCGCAGCACCTGTTGGAGGTCCTGGCCCAGGATCCGTTCACCACCCCACCCAAGTACGAGAAGTTGGTCGGCGCCCTCG
TGGGCTGCTACTCAAGACGCATCAATATCCAGCACCGACTTGTCTATGAGGTGCTCCCTGAGCGCCACGTCGTCCACATT
CTGAGGATGTGGACGCACTGCGAGTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11184.82 Da        Isoelectric Point: 6.2243

>AT236248 WP_000138928.1 NZ_CP092475:661393-661686 [Staphylococcus aureus]
MTEQDIAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT236248 NZ_LR214441:c2142376-2142134 [Tessaracoccus lapidicaptus]
ATGACTGCTGTGAACGCGACGTCTGCCCGGGCGAATCTGTACCGGTTGATCGATCAGGTCAACGAGGAGTCCGAGCCGTT
GACCATCACCGGGCAGCGTGGCAATGCTGTGCTTGTCGGCGAGGAGGACTGGCTGGCCATTCAGGAGACACTGTTCCTGG
AGTCGGTGCCTGGGTTGGCTGAGTCGATCCGTCGTGCCCGCGCGGAGGGTGTCGATGCGGGCTCGACCGAGCTGGACTGG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure

References