Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 4778672..4779260 Replicon chromosome
Accession NZ_CP092466
Organism Citrobacter portucalensis strain Cf7303

Toxin (Protein)


Gene name PumA Uniprot ID A0A5B0T4T9
Locus tag LY264_RS23065 Protein ID WP_032942059.1
Coordinates 4778672..4778989 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A5B0STC7
Locus tag LY264_RS23070 Protein ID WP_032942057.1
Coordinates 4778982..4779260 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LY264_RS23040 (LY264_23035) 4774440..4775264 + 825 WP_048215145.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
LY264_RS23045 (LY264_23040) 4775333..4776556 + 1224 WP_071692186.1 L-sorbose 1-phosphate reductase -
LY264_RS23050 (LY264_23045) 4776558..4777370 + 813 WP_032942070.1 shikimate 5-dehydrogenase -
LY264_RS23055 (LY264_23050) 4777420..4777602 - 183 WP_008786892.1 hypothetical protein -
LY264_RS23060 (LY264_23055) 4777857..4778408 + 552 WP_048215148.1 AAA family ATPase -
LY264_RS23065 (LY264_23060) 4778672..4778989 + 318 WP_032942059.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LY264_RS23070 (LY264_23065) 4778982..4779260 + 279 WP_032942057.1 putative addiction module antidote protein Antitoxin
LY264_RS23075 (LY264_23070) 4779371..4780060 + 690 WP_003841421.1 dipeptidase PepE -
LY264_RS23080 (LY264_23075) 4780227..4781858 - 1632 WP_048213962.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4769337..4779260 9923


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Uncharacterized protein HI1420

(3-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11993.00 Da        Isoelectric Point: 9.6790

>T236234 WP_032942059.1 NZ_CP092466:4778672-4778989 [Citrobacter portucalensis]
IMEILQTMVFRRWEQNLRDRRAKTLIATRLFRLANGLAGDVKPVGEGVSEMRISYGPGYRIYFKQQGCRIIILLCGGDKS
SQANDITLAKMLARTLDSQEIFCHE

Download         Length: 318 bp

>T236234 NZ_LR213458:2947045-2947152 [Shigella sonnei]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9872.45 Da        Isoelectric Point: 5.8233

>AT236234 WP_032942057.1 NZ_CP092466:4778982-4779260 [Citrobacter portucalensis]
MNKLTHYDPATALVDDEEIAVFMADALETGDAAYIAKALGVVARAKGMANIAAETGLSREQLYRSFSEKGNPTLKTTLAV
MKVLGIELTLKK

Download         Length: 279 bp

>AT236234 NZ_LR213458:c2946991-2946935 [Shigella sonnei]
TCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5B0T4T9

Antitoxin

Source ID Structure
AlphaFold DB A0A5B0STC7

References