Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4502033..4502549 Replicon chromosome
Accession NZ_CP092466
Organism Citrobacter portucalensis strain Cf7303

Toxin (Protein)


Gene name relE Uniprot ID A0A6H3ATC4
Locus tag LY264_RS21775 Protein ID WP_048227188.1
Coordinates 4502033..4502317 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A6H3AWC7
Locus tag LY264_RS21780 Protein ID WP_003830370.1
Coordinates 4502307..4502549 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LY264_RS21760 (LY264_21755) 4497245..4498897 + 1653 WP_048215056.1 alpha,alpha-phosphotrehalase -
LY264_RS21765 (LY264_21760) 4499306..4501444 + 2139 WP_048215057.1 anaerobic ribonucleoside-triphosphate reductase -
LY264_RS21770 (LY264_21765) 4501565..4502029 + 465 WP_048227187.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LY264_RS21775 (LY264_21770) 4502033..4502317 - 285 WP_048227188.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LY264_RS21780 (LY264_21775) 4502307..4502549 - 243 WP_003830370.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LY264_RS21785 (LY264_21780) 4502627..4504540 - 1914 WP_048227189.1 BglG family transcription antiterminator -
LY264_RS21790 (LY264_21785) 4504562..4505302 - 741 WP_048227190.1 KDGP aldolase family protein -
LY264_RS21795 (LY264_21790) 4505299..4506417 - 1119 WP_048227191.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LY264_RS21800 (LY264_21795) 4506401..4507534 - 1134 WP_048227192.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-65)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10918.71 Da        Isoelectric Point: 10.0482

>T236232 WP_048227188.1 NZ_CP092466:c4502317-4502033 [Citrobacter portucalensis]
MTYELEFDPRALKEWHKLGDTVKTQFKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVVVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T236232 NZ_LR213458:2339579-2339682 [Shigella sonnei]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8945.35 Da        Isoelectric Point: 5.0651

>AT236232 WP_003830370.1 NZ_CP092466:c4502549-4502307 [Citrobacter portucalensis]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLASPQKGIKVSLDDL

Download         Length: 243 bp

>AT236232 NZ_LR213458:c2339683-2339449 [Shigella sonnei]
TAAAAAAAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCA
TTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAAT
AAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6H3ATC4

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AWC7

References