Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 874187..874841 Replicon chromosome
Accession NZ_CP092466
Organism Citrobacter portucalensis strain Cf7303

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag LY264_RS04245 Protein ID WP_003825515.1
Coordinates 874434..874841 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag LY264_RS04240 Protein ID WP_003825514.1
Coordinates 874187..874453 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LY264_RS04215 (LY264_04215) 869342..870775 - 1434 WP_008785745.1 6-phospho-beta-glucosidase BglA -
LY264_RS04220 (LY264_04220) 870896..871624 - 729 WP_008785744.1 MurR/RpiR family transcriptional regulator -
LY264_RS04225 (LY264_04225) 871677..871988 + 312 WP_048225466.1 N(4)-acetylcytidine aminohydrolase -
LY264_RS04230 (LY264_04230) 872152..872814 + 663 WP_006686898.1 hemolysin III family protein -
LY264_RS04235 (LY264_04235) 872946..873929 - 984 WP_008785741.1 tRNA-modifying protein YgfZ -
LY264_RS04240 (LY264_04240) 874187..874453 + 267 WP_003825514.1 FAD assembly factor SdhE Antitoxin
LY264_RS04245 (LY264_04245) 874434..874841 + 408 WP_003825515.1 protein YgfX Toxin
LY264_RS04250 (LY264_04250) 874943..875464 - 522 WP_003026933.1 flavodoxin FldB -
LY264_RS04255 (LY264_04255) 875578..876474 + 897 WP_003825519.1 site-specific tyrosine recombinase XerD -
LY264_RS04260 (LY264_04260) 876498..877211 + 714 WP_048225463.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LY264_RS04265 (LY264_04265) 877217..878950 + 1734 WP_048225460.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15882.76 Da        Isoelectric Point: 11.3523

>T236219 WP_003825515.1 NZ_CP092466:874434-874841 [Citrobacter portucalensis]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQG

Download         Length: 408 bp

>T236219 NZ_LR213455:3565486-3565704 [Shigella flexneri]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10615.14 Da        Isoelectric Point: 5.1700

>AT236219 WP_003825514.1 NZ_CP092466:874187-874453 [Citrobacter portucalensis]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADEQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT236219 NZ_LR213455:3565086-3565460 [Shigella flexneri]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGTTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGCTCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAACGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References