Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4199806..4200475 Replicon chromosome
Accession NZ_CP092461
Organism Serratia marcescens strain RH10

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag MJ023_RS20340 Protein ID WP_016929976.1
Coordinates 4199806..4200228 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A8G2G4M4
Locus tag MJ023_RS20345 Protein ID WP_004931679.1
Coordinates 4200209..4200475 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJ023_RS20320 (MJ023_004030) 4195696..4196214 + 519 WP_033639477.1 flavodoxin FldB -
MJ023_RS20325 (MJ023_004031) 4196252..4197616 - 1365 WP_243810568.1 cell envelope integrity protein CreD -
MJ023_RS20330 (MJ023_004032) 4197697..4199114 - 1418 Protein_3968 two-component system sensor histidine kinase CreC -
MJ023_RS20335 (MJ023_004033) 4199111..4199806 - 696 WP_123867883.1 two-component system response regulator CreB -
MJ023_RS20340 (MJ023_004034) 4199806..4200228 - 423 WP_016929976.1 protein YgfX Toxin
MJ023_RS20345 (MJ023_004035) 4200209..4200475 - 267 WP_004931679.1 FAD assembly factor SdhE Antitoxin
MJ023_RS20350 (MJ023_004036) 4200796..4201788 + 993 WP_243810569.1 tRNA-modifying protein YgfZ -
MJ023_RS20355 (MJ023_004037) 4201827..4202324 - 498 WP_243810570.1 DUF2165 domain-containing protein -
MJ023_RS20360 (MJ023_004038) 4202475..4203149 - 675 WP_028127690.1 hemolysin III family protein -
MJ023_RS20365 (MJ023_004039) 4203333..4203941 + 609 WP_028127691.1 HD domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16501.62 Da        Isoelectric Point: 11.2159

>T236217 WP_016929976.1 NZ_CP092461:c4200228-4199806 [Serratia marcescens]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLQPMEGKKRRRLWLASDCMSKEEWRHLRQLLLHPPAGNGEEP

Download         Length: 423 bp

>T236217 NZ_LR213455:2646030-2646137 [Shigella flexneri]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTGCCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10387.89 Da        Isoelectric Point: 4.7921

>AT236217 WP_004931679.1 NZ_CP092461:c4200475-4200209 [Serratia marcescens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDGELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT236217 NZ_LR213455:c2645974-2645918 [Shigella flexneri]
TCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References