Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3848709..3849365 Replicon chromosome
Accession NZ_CP092461
Organism Serratia marcescens strain RH10

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MJ023_RS18695 Protein ID WP_243810512.1
Coordinates 3848709..3849098 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8G2LCA8
Locus tag MJ023_RS18700 Protein ID WP_004941563.1
Coordinates 3849102..3849365 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJ023_RS18680 (MJ023_003704) 3845177..3846607 + 1431 WP_060445283.1 multidrug transporter subunit MdtD -
MJ023_RS18685 (MJ023_003705) 3846604..3847986 + 1383 WP_016926705.1 two-component system sensor histidine kinase BaeS -
MJ023_RS18690 (MJ023_003706) 3847986..3848702 + 717 WP_243810511.1 two-component system response regulator BaeR -
MJ023_RS18695 (MJ023_003707) 3848709..3849098 - 390 WP_243810512.1 type II toxin-antitoxin system VapC family toxin Toxin
MJ023_RS18700 (MJ023_003708) 3849102..3849365 - 264 WP_004941563.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MJ023_RS18705 (MJ023_003709) 3849704..3850042 + 339 WP_016926703.1 YegP family protein -
MJ023_RS18710 (MJ023_003710) 3850221..3851573 + 1353 WP_060445282.1 tRNA 5-hydroxyuridine modification protein YegQ -
MJ023_RS18715 (MJ023_003711) 3852041..3852946 + 906 WP_016926701.1 lipid kinase YegS -
MJ023_RS18720 (MJ023_003712) 3853115..3854329 + 1215 WP_016926700.1 D-galactonate dehydratase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14268.54 Da        Isoelectric Point: 7.7781

>T236216 WP_243810512.1 NZ_CP092461:c3849098-3848709 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELLCGVAKRRNKALQSMVEAFLAAVTVYAWDSDAARCYGEM
RATMERKGKIMGAMDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

>T236216 NZ_LR213455:c2514347-2514192 [Shigella flexneri]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10062.31 Da        Isoelectric Point: 4.6702

>AT236216 WP_004941563.1 NZ_CP092461:c3849365-3849102 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Download         Length: 264 bp

>AT236216 NZ_LR213455:2514359-2514417 [Shigella flexneri]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATTTGTGAGACATAGATTGGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References