Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1536935..1537483 Replicon chromosome
Accession NZ_CP092461
Organism Serratia marcescens strain RH10

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag MJ023_RS07450 Protein ID WP_028127948.1
Coordinates 1537181..1537483 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag MJ023_RS07445 Protein ID WP_025302143.1
Coordinates 1536935..1537171 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJ023_RS07430 (MJ023_001478) 1533421..1534956 + 1536 WP_016928459.1 glutathione ABC transporter substrate-binding protein GsiB -
MJ023_RS07435 (MJ023_001479) 1535009..1535929 + 921 WP_016928458.1 glutathione ABC transporter permease GsiC -
MJ023_RS07440 (MJ023_001480) 1535939..1536847 + 909 WP_016928457.1 glutathione ABC transporter permease GsiD -
MJ023_RS07445 (MJ023_001481) 1536935..1537171 + 237 WP_025302143.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
MJ023_RS07450 (MJ023_001482) 1537181..1537483 + 303 WP_028127948.1 CcdB family protein Toxin
MJ023_RS07455 (MJ023_001483) 1537520..1538362 - 843 WP_015377214.1 S-formylglutathione hydrolase -
MJ023_RS07460 (MJ023_001484) 1538377..1539502 - 1126 Protein_1434 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
MJ023_RS07465 (MJ023_001485) 1539532..1540452 - 921 WP_079449477.1 LysR family transcriptional regulator -
MJ023_RS07470 (MJ023_001486) 1540558..1541715 + 1158 WP_033640883.1 YbfB/YjiJ family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-99)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11210.98 Da        Isoelectric Point: 5.0196

>T236206 WP_028127948.1 NZ_CP092461:1537181-1537483 [Serratia marcescens]
ITVYDNTYPASAYPYLLDVQSDLIDVLSTRLMIPLYALDNVRVKISARLCPEIEVNGEKFLVMTHEMAAVRISQIGKAVG
NVNEHRNQIKAAIDFLIDGF

Download         Length: 303 bp

>T236206 NZ_LR213452:3472830-3473228 [Shigella flexneri]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAGCCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGAAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8967.04 Da        Isoelectric Point: 5.0807

>AT236206 WP_025302143.1 NZ_CP092461:1536935-1537171 [Serratia marcescens]
MANSNVTKKTVNVTIDRDLFQRAKSLGVNVSSVLTDALSVRVRDIEIQQWREQNRAALEELNRITEENGLLSDEYRTF

Download         Length: 237 bp

>AT236206 NZ_LR213452:3472534-3472827 [Shigella flexneri]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
AGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTTCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
AAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References