Detailed information of TA system TA236205

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 1408477..1409044
• Replicon: chromosome
• Accession: NZ_CP092461
• Organism: Serratia marcescens strain RH10

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: MJ023_RS06780
• Protein ID: WP_072270879.1
• Coordinates: 1408477..1408782 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A8B4G8D1
• Locus tag: MJ023_RS06785
• Protein ID: WP_016928576.1
• Coordinates: 1408784..1409044 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MJ023_RS06745 (MJ023_001342)	1404125..1405201	+	1077	WP_048796603.1	urea ABC transporter permease subunit UrtC	-
MJ023_RS06750 (MJ023_001343)	1405198..1406004	+	807	WP_015377102.1	urea ABC transporter ATP-binding protein UrtD	-
MJ023_RS06755 (MJ023_001344)	1406017..1406715	+	699	WP_147881603.1	urea ABC transporter ATP-binding subunit UrtE	-
MJ023_RS06760	1406837..1407022	-	186	WP_232065802.1	type II toxin-antitoxin system RelE/ParE family toxin	-
MJ023_RS06765 (MJ023_001346)	1407007..1407270	-	264	WP_004939442.1	type II toxin-antitoxin system ParD family antitoxin	-
MJ023_RS06770 (MJ023_001347)	1407405..1407917	+	513	WP_033640967.1	DUF2165 family protein	-
MJ023_RS06775 (MJ023_001348)	1407940..1408452	-	513	WP_243811031.1	GNAT family N-acetyltransferase	-
MJ023_RS06780 (MJ023_001349)	1408477..1408782	-	306	WP_072270879.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MJ023_RS06785 (MJ023_001350)	1408784..1409044	-	261	WP_016928576.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MJ023_RS06790 (MJ023_001351)	1409113..1410348	-	1236	WP_161544522.1	FAD-dependent oxidoreductase	-
MJ023_RS06795 (MJ023_001352)	1410425..1410994	-	570	WP_016928574.1	DUF4865 family protein	-
MJ023_RS06800 (MJ023_001353)	1411100..1411969	+	870	WP_033640963.1	LysR substrate-binding domain-containing protein	-
MJ023_RS06805 (MJ023_001354)	1411966..1412811	-	846	WP_033640962.1	3-mercaptopyruvate sulfurtransferase	-
MJ023_RS06810 (MJ023_001355)	1412918..1413343	+	426	WP_033641463.1	NUDIX hydrolase	-
MJ023_RS06815 (MJ023_001356)	1413351..1414016	-	666	WP_033640961.1	epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-92)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-65)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11927.69 Da
• Isoelectric Point: 9.5902

>T236205 WP_072270879.1 NZ_CP092461:c1408782-1408477 [Serratia marcescens]
MPAFRLTPQAQQDLLAIRHFTIEHWGQAQSRRYLEQLREVMHHLADMPEAGKAHFHDLGEEIRSFPYASHRIYYRSRPAG
ITVLAILHQAMVPHRHLEQRL

Nucleotide

• Length: 306 bp

>T236205 NZ_LR213452:3391669-3391827 [Shigella flexneri]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCTACGCGCATCGCTAAAGAAAAGTGTGCGTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9442.59 Da
• Isoelectric Point: 4.1964

>AT236205 WP_016928576.1 NZ_CP092461:c1409044-1408784 [Serratia marcescens]
MYALTANEAKTQFGDLLLKAQREPVQINRNGKPVAVVMSVEDYQALEDLKLSALQQKIAQATAEEDAGKAVDGDAFFNRL
LTDETD

Nucleotide

• Length: 261 bp

>AT236205 NZ_LR213452:3391374-3391685 [Shigella flexneri]
ATGCCTGGAAAAACAGCCGCTCTATACGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Structures

Antitoxin

• AlphaFold DB: A0A8B4G8D1