Detailed information of TA system TA236203

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 55067..55602
• Replicon: chromosome
• Accession: NZ_CP092461
• Organism: Serratia marcescens strain RH10

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A5C7D971
• Locus tag: MJ023_RS00240
• Protein ID: WP_033636570.1
• Coordinates: 55327..55602 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8G2GBD7
• Locus tag: MJ023_RS00235
• Protein ID: WP_033639076.1
• Coordinates: 55067..55327 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MJ023_RS00215 (MJ023_000043)	50393..51043	+	651	WP_033639079.1	DcrB-related protein	-
MJ023_RS00220 (MJ023_000044)	51079..51684	+	606	WP_212562979.1	glutathione S-transferase	-
MJ023_RS00225 (MJ023_000045)	51751..53145	+	1395	WP_060444908.1	L-seryl-tRNA(Sec) selenium transferase	-
MJ023_RS00230 (MJ023_000046)	53142..54984	+	1843	Protein_45	selenocysteine-specific translation elongation factor	-
MJ023_RS00235 (MJ023_000047)	55067..55327	+	261	WP_033639076.1	ribbon-helix-helix domain-containing protein	Antitoxin
MJ023_RS00240 (MJ023_000048)	55327..55602	+	276	WP_033636570.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MJ023_RS00245 (MJ023_000049)	55614..56525	-	912	WP_033639075.1	LysR family transcriptional regulator	-
MJ023_RS00250 (MJ023_000050)	56647..57273	+	627	WP_147827644.1	LysE family translocator	-
MJ023_RS00255 (MJ023_000051)	57327..58574	-	1248	WP_028127797.1	MFS transporter	-
MJ023_RS00260 (MJ023_000052)	58792..59784	+	993	WP_115116352.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-43)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10578.32 Da
• Isoelectric Point: 10.3377

>T236203 WP_033636570.1 NZ_CP092461:55327-55602 [Serratia marcescens]
MELKWTSKALSDLARLFEFLALANRTAAANSVKALVAAPKALLDNPRLGERLDEFLPQEVRRILVGRYEIRYQVQPATIY
VLRIWHTREER

Nucleotide

• Length: 276 bp

>T236203 NZ_LR213452:3072443-3072712 [Shigella flexneri]
TTGAGTATGCGTGCCAGATACCAGCATCTTGTTGAACGCATGAAGGTATACGGCAGCAATCTCGGAGAACCTCACACCAG
CGCCTTTGGTGACGGGCTTTTCGAACTCAGAATTAAAGGCAACGATGGGATCGCGCGTGTTTTTTACTGCACTCTGACAG
GGAAACGCATCATCATGCTGCATAGTTTTGTAAAGAAAGCGCAGAAAACACCGCCAGCCGAACGCAAGAAAGCTGAAACC
AGAATGAAGGAGGTTAAGCATGACTGGTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9682.01 Da
• Isoelectric Point: 4.5317

>AT236203 WP_033639076.1 NZ_CP092461:55067-55327 [Serratia marcescens]
MNTKVITAHVPLPLAEKVDEMAAKLERSRGWIVKQALAAWLEQEEERRRLTLAALADVEQQNVIDHESVEAWAASLDSDE
PLPVPR

Nucleotide

• Length: 261 bp

>AT236203 NZ_LR213452:3072702-3073010 [Shigella flexneri]
ATGACTGGTAAACGCACTCTCCCCACCATGACACACGACGAAATGGCAGCCAAATGGATGGAAGACCCGGCTTTTAAAGC
AGAATACGACGCTATCGCTGACGAATTCGCACTGCTTGATGAAATGCTGGCAGCACGCAAAGAAGCTGGCTTAACTCAGG
CTGAAGTTGCCGAGCGAATGGGAACAAAAGCGACCGCGATCACCAGAATGGAAAGTAATCTCGCATCAGGTATCAGCGGC
CCATCATTTGCCACACTAAAAAAATTCGCCCGCGCTACTGGAAAAAAACTCCAGATCCGCTTCGTTTAA

Structures

Toxin

• AlphaFold DB: A0A5C7D971