Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4033664..4034301 Replicon chromosome
Accession NZ_CP092460
Organism Dickeya fangzhongdai strain AP6

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag FXN80_RS17870 Protein ID WP_161129963.1
Coordinates 4033664..4034074 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag FXN80_RS17875 Protein ID WP_161129964.1
Coordinates 4034071..4034301 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FXN80_RS17840 (FXN80_17840) 4028835..4029737 + 903 WP_161129957.1 LysR substrate-binding domain-containing protein -
FXN80_RS17845 (FXN80_17845) 4029867..4030205 - 339 WP_161129958.1 carboxymuconolactone decarboxylase family protein -
FXN80_RS17850 (FXN80_17850) 4030222..4030791 - 570 WP_161129959.1 TetR/AcrR family transcriptional regulator -
FXN80_RS17855 (FXN80_17855) 4030981..4031538 - 558 WP_161129960.1 OsmC family protein -
FXN80_RS17860 (FXN80_17860) 4031924..4032391 + 468 WP_161129961.1 GNAT family N-acetyltransferase -
FXN80_RS17865 (FXN80_17865) 4032525..4033505 - 981 WP_161129962.1 restriction endonuclease -
FXN80_RS17870 (FXN80_17870) 4033664..4034074 - 411 WP_161129963.1 PIN domain-containing protein Toxin
FXN80_RS17875 (FXN80_17875) 4034071..4034301 - 231 WP_161129964.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FXN80_RS17880 (FXN80_17880) 4035371..4036534 - 1164 WP_161129965.1 tyrosine-type recombinase/integrase -
FXN80_RS17890 (FXN80_17890) 4036929..4038182 - 1254 WP_121480525.1 glutamate-5-semialdehyde dehydrogenase -
FXN80_RS17895 (FXN80_17895) 4038193..4039296 - 1104 WP_038919997.1 glutamate 5-kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-127)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14408.36 Da        Isoelectric Point: 4.5355

>T236202 WP_161129963.1 NZ_CP092460:c4034074-4033664 [Dickeya fangzhongdai]
VNRTYMLDTRFCAFILREQPEAVLGRLEQAVLRGHRIVISAVTWAELSQAAREDSPATQALADAFCASLDAVLPWDRAAV
DATTEIKAALAATGTPLGPNDAAIAGHAIAAGAVLVTRNGEEFERVPGLILQDWAG

Download         Length: 411 bp

>T236202 NZ_LR213452:c2686129-2685755 [Shigella flexneri]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGTCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8634.83 Da        Isoelectric Point: 4.7863

>AT236202 WP_161129964.1 NZ_CP092460:c4034301-4034071 [Dickeya fangzhongdai]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDCIILRPVRPAWSSFALMDRAGPEFMAEREVVISDNGRGEQ

Download         Length: 231 bp

>AT236202 NZ_LR213452:c2686550-2686176 [Shigella flexneri]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGTATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References