Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2196846..2197534 Replicon chromosome
Accession NC_012207
Organism Mycobacterium bovis BCG str. Tokyo 172

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag JTY_RS10230 Protein ID WP_003409958.1
Coordinates 2196846..2197265 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag JTY_RS10235 Protein ID WP_003409968.1
Coordinates 2197274..2197534 (-) Length 87 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JTY_RS10205 2191852..2192157 + 306 Protein_1991 ABC transporter permease -
JTY_RS10210 2192341..2193189 + 849 WP_003409942.1 class I SAM-dependent methyltransferase -
JTY_RS10215 2193152..2194597 - 1446 WP_003409946.1 APC family permease -
JTY_RS10220 2194776..2195462 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
JTY_RS10225 2195653..2196621 - 969 WP_003409956.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
JTY_RS10230 2196846..2197265 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
JTY_RS10235 2197274..2197534 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JTY_RS10240 2197677..2199353 + 1677 WP_010950639.1 PecA family PE domain-processing aspartic protease -
JTY_RS10245 2199341..2199994 - 654 WP_003409976.1 cutinase Cfp21 -
JTY_RS10250 2200109..2200339 + 231 WP_003409980.1 DUF167 domain-containing protein -
JTY_RS10255 2200424..2201335 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
JTY_RS10260 2201444..2202043 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-125)

Antitoxin

(2-81)


Sequences


Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T23620 WP_003409958.1 NC_012207:c2197265-2196846 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T23620 NC_012207:c2197265-2196846 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
ATGATCGTGGACACAAGCGCCGTGGTGGCCCTGGTTCAAGGCGAGCGGCCGCACGCCACCCTGGTCGCGGCCGCCCTGGC
CGGCGCCCATAGCCCCGTCATGTCTGCACCCACCGTCGCCGAATGCCTGATTGTCTTGACCGCCCGTCACGGCCCCGTTG
CGCGCACGATCTTCGAACGACTTCGCAGCGAAATCGGCTTGAGCGTGTCATCTTTCACCGCCGAGCATGCCGCTGCCACG
CAACGAGCCTTTCTGCGATACGGCAAGGGGCGCCACCGCGCGGCTCTCAACTTCGGAGACTGTATGACGTACGCGACCGC
CCAGCTGGGCCACCAACCACTGCTGGCCGTCGGCAACGACTTCCCGCAAACCGACCTTGAGTTCCGCGGCGTCGTCGGCT
ACTGGCCAGGCGTCGCGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT23620 WP_003409968.1 NC_012207:c2197534-2197274 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT23620 NC_012207:c2197534-2197274 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
GTGGCGCTGAATATCAAAGACCCTGAGGTAGACCGACTAGCCGCCGAACTCGCTGACCGGCTGCACACCAGCAAGACTGC
CGCCATCCGGCATGCCCTGTCTGCCCAGCTGGCGTTTTTGGAGTCGCGCGCCGGCGACCGTGAGGCACAACTTCTCGACA
TCTTGCGTACCGAAATCTGGCCCCTGCTTGCCGACCGCTCCCCCATCACCAAGCTCGAGCGCGAACAAATCCTCGGCTAC
GACCCCGCAACCGGAGTCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A829C4H9


Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References