Detailed information of TA system TA236193

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 1956823..1957376
• Replicon: chromosome
• Accession: NZ_CP092460
• Organism: Dickeya fangzhongdai strain AP6

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: FXN80_RS08645
• Protein ID: WP_161130539.1
• Coordinates: 1957062..1957376 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: FXN80_RS08640
• Protein ID: WP_027712563.1
• Coordinates: 1956823..1957059 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FXN80_RS08630 (FXN80_08630)	1952535..1954844	-	2310	WP_161130541.1	TerB N-terminal domain-containing protein	-
FXN80_RS08635 (FXN80_08635)	1955561..1956505	+	945	WP_161130540.1	zincin-like metallopeptidase domain-containing protein	-
FXN80_RS08640 (FXN80_08640)	1956823..1957059	+	237	WP_027712563.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
FXN80_RS08645 (FXN80_08645)	1957062..1957376	+	315	WP_161130539.1	CcdB family protein	Toxin
FXN80_RS08650 (FXN80_08650)	1957373..1957507	-	135	Protein_1692	mobilization protein mobC	-
FXN80_RS08655 (FXN80_08655)	1957675..1957866	+	192	Protein_1693	baseplate protein	-
FXN80_RS08660 (FXN80_08660)	1957980..1958285	+	306	WP_161130538.1	hypothetical protein	-
FXN80_RS08665 (FXN80_08665)	1958338..1959057	+	720	WP_161130537.1	hypothetical protein	-
FXN80_RS08670 (FXN80_08670)	1959422..1960168	-	747	WP_161130536.1	MobC family replication-relaxation protein	-
FXN80_RS08675 (FXN80_08675)	1960177..1961940	-	1764	WP_161130535.1	type IV secretion system DNA-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	hcp / vgrG1	1942442..1993106	50664

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-103)

Antitoxin

• Post-segregation antitoxin CcdA (9-78)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11500.43 Da
• Isoelectric Point: 7.9859

>T236193 WP_161130539.1 NZ_CP092460:1957062-1957376 [Dickeya fangzhongdai]
MQFTVYGNTGKSAIYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPAGRRPERLVPVVRLTDGKEYAVMTHELASIPVQALG
AVFCDASQYRNQVKAAIDFLIDGI

Nucleotide

• Length: 315 bp

>T236193 NZ_LR213452:206921-207028 [Shigella flexneri]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9076.08 Da
• Isoelectric Point: 5.6998

>AT236193 WP_027712563.1 NZ_CP092460:1956823-1957059 [Dickeya fangzhongdai]
MTVKQRNTQSVTMTVERALLVRAREAGINLSATLSTALDAELRRYEANKWQEENREAIDALNRFHDEHGCFSDEYRTF

Nucleotide

• Length: 237 bp

>AT236193 NZ_LR213452:c206872-206806 [Shigella flexneri]
GTCTAGGTTCAAGATTAGCCCCCGTTATGTTGTCAGGTACATACCTGCAACGTGCGGGGGTTTTCTC