Detailed information of TA system TA236192

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DhiAT/dnstrm_HI1420(antitoxin)
• Location: 1772246..1772999
• Replicon: chromosome
• Accession: NZ_CP092460
• Organism: Dickeya fangzhongdai strain AP6

Toxin (Protein)

• Gene name: dhiT
• Uniprot ID: -
• Locus tag: FXN80_RS07845
• Protein ID: WP_107759008.1
• Coordinates: 1772246..1772503 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: dhiA
• Uniprot ID: A0A2K8QKC0
• Locus tag: FXN80_RS07850
• Protein ID: WP_038918520.1
• Coordinates: 1772511..1772999 (+)
• Length: 163 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FXN80_RS07835 (FXN80_07835)	1769021..1771171	-	2151	WP_049854965.1	formate dehydrogenase subunit alpha	-
FXN80_RS07840 (FXN80_07840)	1771206..1771748	-	543	WP_107759007.1	4Fe-4S dicluster domain-containing protein	-
FXN80_RS07845 (FXN80_07845)	1772246..1772503	+	258	WP_107759008.1	DUF4160 domain-containing protein	Toxin
FXN80_RS07850 (FXN80_07850)	1772511..1772999	+	489	WP_038918520.1	addiction module antitoxin	Antitoxin
FXN80_RS07855 (FXN80_07855)	1773084..1773581	-	498	WP_038918521.1	hydrogenase maturation peptidase HycI	-
FXN80_RS07860 (FXN80_07860)	1773574..1773972	-	399	WP_038660229.1	formate hydrogenlyase maturation HycH family protein	-
FXN80_RS07865 (FXN80_07865)	1773969..1774760	-	792	WP_038918522.1	NADH-quinone oxidoreductase subunit B family protein	-
FXN80_RS07870 (FXN80_07870)	1774757..1775326	-	570	WP_039691199.1	hydrogenase 4 subunit H	-
FXN80_RS07875 (FXN80_07875)	1775337..1777064	-	1728	WP_161131015.1	hydrogenase large subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF4160 (9-74)

Antitoxin

• Uncharacterized protein HI1420 (79-157)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9995.55 Da
• Isoelectric Point: 8.1489

>T236192 WP_107759008.1 NZ_CP092460:1772246-1772503 [Dickeya fangzhongdai]
MPEIDRLAGLIFHLYFYDDERHHLPHVHVCYGNHELIISIRTGTEIEGYLPNNKRKMALAHIRAHREQLLSMWERAVVGR
NPGKL

Nucleotide

• Length: 258 bp

>T236192 NZ_LR136958:2718913-2719191 [Alteromonas sp. 76-1]
ATGATTAAGAGTTTTATACATAAAGGCCTTCAGAAGTTTTACGCTAAAGGAGCCACTTCAGGAATTCAGAAAAAGCACGA
AAAAAAGCTTCGTCTTATTCTGTCGAATCTCGATCAAGCTGAAACACCTGATGACATGGATTTACCCGGCCTTTATATGC
ACAAACTCAAAGGTAACAGAAATGATATTTGGTCTGTTCGGGTAAGTGGAAACTGGAGAGTTACATACCGCTTTGTTGGA
CGAGATGTTGAAATCGTTAATTACGAGGATTACCACTAA

Antitoxin

Protein

• Length: 163 a.a.
• Molecular weight: 17940.51 Da
• Isoelectric Point: 6.9795

>AT236192 WP_038918520.1 NZ_CP092460:1772511-1772999 [Dickeya fangzhongdai]
MHKIVEVDVIGDFSLRLTYEDGLVCDINLYQYASSPVFSNASLFIKFGLLPDGSLEWSPDIKISASELRKKGEYVSHTLA
VREKNFADVISRAFYDAVIENRPEILQAALKIAVEKHGNSTVAKEAGAKSRTSLYKSLNKNTHVSLATVVSLAHTVLQLE
EK

Nucleotide

• Length: 489 bp

>AT236192 NZ_LR136958:2719191-2719487 [Alteromonas sp. 76-1]
ATGAATATGCATAACCCTGCGCATCCCGGTGAGATACTCAAAGATCTTGTTATTGATGCTCTAGAACTGACTATTACTGA
TGTAGCGCAACATTTAGATGTGAGCCGTAAAACATTATCGAAAGTTCTTAATGGCAAAGGGGCTATTACTCCAGAGATGG
CTCTTCGTCTTGAACTCGTTTTCGGTAAGCCTTCTGCGGCCCATTGGCTTCGTTTGCAAAATGCATTTGATTTGTGGCAA
ACAAGACAATATCAAAGCTCTTTACATGTCTCACCGTATAATTTGGCTAAGGTATAA

Structures

Antitoxin

• AlphaFold DB: A0A2K8QKC0