236191

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1307843..1308468 Replicon chromosome
Accession NZ_CP092460
Organism Dickeya fangzhongdai strain AP6

Toxin (Protein)


Gene name Hha Uniprot ID E0SD87
Locus tag FXN80_RS05935 Protein ID WP_009114000.1
Coordinates 1307843..1308046 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2K8QJA5
Locus tag FXN80_RS05940 Protein ID WP_042859087.1
Coordinates 1308100..1308468 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FXN80_RS05905 (FXN80_05905) 1303481..1303819 + 339 WP_002208627.1 P-II family nitrogen regulator -
FXN80_RS05910 (FXN80_05910) 1303862..1305154 + 1293 WP_038661206.1 ammonium transporter AmtB -
FXN80_RS05915 (FXN80_05915) 1305247..1306110 - 864 WP_038918195.1 acyl-CoA thioesterase II -
FXN80_RS05920 (FXN80_05920) 1306363..1306923 + 561 WP_038918196.1 YbaY family lipoprotein -
FXN80_RS05925 (FXN80_05925) 1306952..1307281 - 330 WP_038918197.1 MGMT family protein -
FXN80_RS05935 (FXN80_05935) 1307843..1308046 - 204 WP_009114000.1 HHA domain-containing protein Toxin
FXN80_RS05940 (FXN80_05940) 1308100..1308468 - 369 WP_042859087.1 Hha toxicity modulator TomB Antitoxin
FXN80_RS05945 (FXN80_05945) 1308976..1309119 - 144 WP_013316871.1 type B 50S ribosomal protein L36 -
FXN80_RS05950 (FXN80_05950) 1309135..1309386 - 252 WP_038661187.1 type B 50S ribosomal protein L31 -
FXN80_RS05955 (FXN80_05955) 1309557..1312703 - 3147 WP_038918200.1 efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8133.51 Da        Isoelectric Point: 8.8500

>T236191 WP_009114000.1 NZ_CP092460:c1308046-1307843 [Dickeya fangzhongdai]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWKYVR

Download         Length: 204 bp

>T236191 NZ_LR136958:c2193611-2193114 [Alteromonas sp. 76-1]
ATAATGAATACGGTACTGCTAGATAAAGCTAAACACGATAGAAACCGATTCAACTGTGGCATCGAAGCTCTCAATAATTA
CTTTAAGGTAATAACGAGTCAGCAAGCAAAGAAAGACAACACCAGAACGTTTGTTTTGGAAGATGATAGCGACAACTCAC
ATGTCATCGGCTTTTACACGCTAACAATGACACCAATTGACTTACAGGCATTGCCTGATAAGTTACAAAAAAAGCACCAA
TCATCCACTTCTGGTGGTCTGATTGCCCGTCTTGCTGTCGATGACCGATACAAAGGGAAAGGCTTTGGTGAGTGGCTGCT
TATCGACGCACTCACAAAGCTATTAGCCGCTAGTGATAGTGTTGCATTTCCAGTTGTTATTGTTGATGCCAAAGACGGAG
CAAAACATTTCTATGAACGCTATGGTTTTCAGGCATTTCAAGACGCTGAAAACAAACTCTTCATTTCCATTGCAGATGTG
AGACCAAGCTTAGGCTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14200.07 Da        Isoelectric Point: 5.1811

>AT236191 WP_042859087.1 NZ_CP092460:c1308468-1308100 [Dickeya fangzhongdai]
MDEYTPQHYDIAQLRFLCENLHDESIATLGDSSRGWVNDPTSAVNLQLNELIEHIAAFVVTYKIKYPHEAALCERVEKYL
DDTYILFSNYGINDSELQKWKKSKSQLFRMFSEKSICTVVKT

Download         Length: 369 bp

>AT236191 NZ_LR136958:c2193880-2193608 [Alteromonas sp. 76-1]
ATGGCTACTACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACACAAGACTTACTTACTAAGGCGGCCGCGATTGC
CGGCATGTCTAGCATCAACTCGTTTGTTCTAAGCGCTGCAATCGAAAAAGCTAAACAAGTTATCGAACGTGAACAGGCTT
TAAAACTGAGCCAAGCTGACGCGATGTTGCTTATGGAAGCTTTAGACTGTACTGCAACACAGAACTCAAAACTAAAAGCT
GCTGCTGATCGATACGATAGCAAAACTCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X3RNQ0

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8QJA5

References