Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 809291..809969 Replicon chromosome
Accession NZ_CP092460
Organism Dickeya fangzhongdai strain AP6

Toxin (Protein)


Gene name cptA Uniprot ID A0A2K8QJH4
Locus tag FXN80_RS03790 Protein ID WP_049854564.1
Coordinates 809538..809969 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A2K8QSU7
Locus tag FXN80_RS03785 Protein ID WP_023637600.1
Coordinates 809291..809557 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FXN80_RS03765 (FXN80_03765) 805737..806387 + 651 WP_049854566.1 LysE family translocator -
FXN80_RS03770 (FXN80_03770) 806458..807066 - 609 WP_038917841.1 HD domain-containing protein -
FXN80_RS03775 (FXN80_03775) 807277..807927 + 651 WP_038917842.1 hemolysin III family protein -
FXN80_RS03780 (FXN80_03780) 808000..808980 - 981 WP_161130565.1 tRNA-modifying protein YgfZ -
FXN80_RS03785 (FXN80_03785) 809291..809557 + 267 WP_023637600.1 FAD assembly factor SdhE Antitoxin
FXN80_RS03790 (FXN80_03790) 809538..809969 + 432 WP_049854564.1 protein YgfX Toxin
FXN80_RS03795 (FXN80_03795) 810069..810587 - 519 WP_107758698.1 flavodoxin FldB -
FXN80_RS03800 (FXN80_03800) 810716..812041 - 1326 WP_161130564.1 MFS transporter -
FXN80_RS03805 (FXN80_03805) 812304..813203 + 900 WP_038917846.1 site-specific tyrosine recombinase XerD -
FXN80_RS03810 (FXN80_03810) 813292..814008 + 717 WP_049854562.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-132)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 16793.54 Da        Isoelectric Point: 11.7737

>T236190 WP_049854564.1 NZ_CP092460:809538-809969 [Dickeya fangzhongdai]
VAQWQCDLRVSWRMQLFSLLTHGFLVLMILLAPWPDGYAPLWLGLVTLVVFGFVRSQRIIKSRQGEISLHGENQLHWQQR
DWQIARRPWVMRNGVLLSLRATTGKGHQRLWLASDSMGNEEWRLLRQLLLQHPLQGTESSRHH

Download         Length: 432 bp

>T236190 NZ_LR136958:c94188-92902 [Alteromonas sp. 76-1]
ATGGAGCTGATGGTAAGCCTTAACGGGGTAAAAGTAGGTACACTGTTAAAAGATAAGAGCGGTGGGCTCCATTTTTCTTA
TACCGAACGTTGGATGAAGCGCGCAGGCGCACGTCCTATTTCTTTGTCGCTACCTATTACAAAGCAAAAATACGCTGGCG
ACGTAGTGTATAACTTCTTCGACAATTTGCTTCCCGATAGTCTAACCATACGAAATAAAATACAAGCTAGGTTCAATGTA
GGCTCTGGACATGCGTTCGATCTTTTAGCGGCGATAGGCAAAGATTGTGTGGGCGCTATTCAATTAGCCTCAGAACAAAC
CGAGTCTGTACAACAACTAAACTATAAGGTTCTGTCAGATCTAGACGTTGAGAAGTTATTGCAAGGCTACAAACATACAG
CGCTTGGAATGGAAAATGACGATGATGACTTTCGGATTTCAATTGCTGGCGCCCAGGAAAAAACCGCGCTACTTAAAACA
GGTCAACAATGGGCGAAGCCGACGGGCTCAACACCAACAAGTCACATAATGAAATTACCCATGGGCGAGTTACCGCAAGT
GGGTATCGATTTAACCGATAGTTGTGAGAACGAATTTATTTGCCTAGAGCTGGCGAGAACCTTTGGTTTTAATGTGGCTA
ATTCAGAGGTGCTTTACTTTGGTGACCAGAAAGTTCTAAGCGTTGAACGCTTTGACCGTAAATACGCATCTGACGGTTCA
TGGCTCATGCGTCTACCCCAAGAAGACTTTTGTCAGGCAATGGGCATTTCATCTGCTCAAAAATACCAATCTGATGGTGG
CCCAGGAATTAAGGACTGCTTAAATTTGCTCACGGCTTCGTCTAACGGGAAAGATAGAGAAACTTTTTTTAGGGCTCAGA
TATTTTTTTGGCTCATTGCCGCTATTGACGGTCATGGTAAGAATTTTAGCGTATTTCTAGAGCCTGAAAACACATATAAA
ATGACCCCTTTATATGATGTCTTGTCGGCGTTTCCTGTAATGACTAAAAAAGCCTTACAGCCGCAAAAGATTAAAATGGC
CATGTCTTTAAAAGGCAAAAATACGCACTGGAAATGGAACGATATTCAGCCTCGTCATTTTGTATCGACTGCATTGCAGG
TGAAATACCCTTCGGACAAAGCTGCATCACACTACGAATACTTTGTCGATAATATTGAAAACGCTATTGCTAAAGTCGAA
GGTAAAATTCCCGATAACTTTCCACCCTACGTAGCGGAGGCAATATTTTCTGGACTGAGAAAGCAAGCATCTAAAAAGTT
GTTTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10544.03 Da        Isoelectric Point: 5.5535

>AT236190 WP_023637600.1 NZ_CP092460:809291-809557 [Dickeya fangzhongdai]
MDINNKSRIHWACRRGMRELDISIMPFFEHEYDTLSDDDKQHFIRLLQCDDPDLFNWLMNHGEPVDPELKRMVSLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT236190 NZ_LR136958:c94450-94190 [Alteromonas sp. 76-1]
ATGAAGCTTAATAACTCAAAAGAACTGGCTGATTATATAAAGCTGCATCGAAATAATCTGGCACGAACGCAGACCGATGT
GGCCGAGCATGTTGGTTTAAAGCAAAAAACCATCTCGGCTATTGAAAATTCTGCCGGTACCTCCCGTATTGATACCCTCT
TTAAAATTGCGCATGAACTCGGTCTCTCTATTGAACTTAAGCCAAAGCAAGAAAATGAAAGCGGCCAAAAGACTGATAGT
GGCTGGGTTCAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8QJH4

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8QSU7

References