Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2187832..2188376 | Replicon | chromosome |
| Accession | NC_012207 | ||
| Organism | Mycobacterium bovis BCG str. Tokyo 172 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | JTY_RS10170 | Protein ID | WP_003409896.1 |
| Coordinates | 2187832..2188128 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | JTY_RS10175 | Protein ID | WP_003409899.1 |
| Coordinates | 2188125..2188376 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JTY_RS10115 | 2182865..2183215 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| JTY_RS10120 | 2183226..2184128 | - | 903 | WP_003409874.1 | hypothetical protein | - |
| JTY_RS10125 | 2184149..2184340 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| JTY_RS10130 | 2184341..2184637 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| JTY_RS10135 | 2184877..2185092 | + | 216 | WP_003409878.1 | antitoxin | - |
| JTY_RS10140 | 2185089..2185400 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| JTY_RS22240 | 2185374..2185895 | - | 522 | WP_010950637.1 | hypothetical protein | - |
| JTY_RS10150 | 2185870..2186247 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| JTY_RS10155 | 2186289..2186738 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| JTY_RS10160 | 2186735..2187280 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| JTY_RS10165 | 2187169..2187783 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| JTY_RS10170 | 2187832..2188128 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| JTY_RS10175 | 2188125..2188376 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| JTY_RS10180 | 2188363..2188857 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| JTY_RS10185 | 2189017..2189424 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| JTY_RS10190 | 2189428..2189700 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| JTY_RS10195 | 2189733..2190953 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| JTY_RS10205 | 2191852..2192157 | + | 306 | Protein_1991 | ABC transporter permease | - |
| JTY_RS10210 | 2192341..2193189 | + | 849 | WP_003409942.1 | class I SAM-dependent methyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T23619 WP_003409896.1 NC_012207:c2188128-2187832 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T23619 NC_012207:c2188128-2187832 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT23619 WP_003409899.1 NC_012207:c2188376-2188125 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT23619 NC_012207:c2188376-2188125 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |