Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 423915..424951 Replicon chromosome
Accession NZ_CP092460
Organism Dickeya fangzhongdai strain AP6

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag FXN80_RS01925 Protein ID WP_049855243.1
Coordinates 424376..424951 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag FXN80_RS01920 Protein ID WP_038917616.1
Coordinates 423915..424376 (+) Length 154 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FXN80_RS01900 (FXN80_01900) 418962..419885 + 924 WP_100848747.1 type I-E CRISPR-associated endonuclease Cas1e -
FXN80_RS01905 (FXN80_01905) 419882..420175 + 294 WP_012883104.1 type I-E CRISPR-associated endoribonuclease Cas2e -
FXN80_RS01910 (FXN80_01910) 421691..423367 - 1677 WP_161130666.1 methyl-accepting chemotaxis protein -
FXN80_RS01915 (FXN80_01915) 423539..423649 - 111 Protein_369 hypothetical protein -
FXN80_RS01920 (FXN80_01920) 423915..424376 + 462 WP_038917616.1 helix-turn-helix domain-containing protein Antitoxin
FXN80_RS01925 (FXN80_01925) 424376..424951 + 576 WP_049855243.1 PIN domain-containing protein Toxin
FXN80_RS01930 (FXN80_01930) 425175..425627 + 453 WP_038917619.1 YhbP family protein -
FXN80_RS01935 (FXN80_01935) 425739..426203 - 465 WP_038917620.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
FXN80_RS01940 (FXN80_01940) 426302..428440 - 2139 WP_049855245.1 anaerobic ribonucleoside-triphosphate reductase -
FXN80_RS01945 (FXN80_01945) 428820..429728 + 909 WP_049855246.1 homocysteine S-methyltransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-115)

Antitoxin

SinI-like, DNA-binding domain

(84-131)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21659.95 Da        Isoelectric Point: 4.8531

>T236188 WP_049855243.1 NZ_CP092460:424376-424951 [Dickeya fangzhongdai]
MTHTPYPVVLDACVIYPSLLRDLLIHLGLTGLYQPKWTAIIEDEWQRNLLLNRPDLTPEQISRTRELMNQAIPDAMITGF
EALIPGITLPDPDDQHVVAAAIRSNAEIIVTFNLKDFPHPEIDNFGIEALHPDDFITDLLDLNQALVLSAVSRQRHSMRK
PPKSVDEYLDALLRQSLPQTVKELSKFHTLI

Download         Length: 576 bp

>T236188 NZ_LR135782:189515-189781 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAATCGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCACCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTGGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 154 a.a.        Molecular weight: 16913.27 Da        Isoelectric Point: 6.2221

>AT236188 WP_038917616.1 NZ_CP092460:423915-424376 [Dickeya fangzhongdai]
MTNSILDSLSLPAPGEIEAAVRGQRELAAYLSTKMETQKISIQDADNNTRQVELPTSALTLLMSILGELAVGNAVQVVPV
HAELTTQEAANILNVSRPHMVKLLEDGKLPFHKTGRHRRVLFADLMDYKHQRDNESSRAMQALADHSQELGLY

Download         Length: 462 bp

>AT236188 NZ_LR135782:189252-189515 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACAGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTAGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTGGCTTTACGAATATCGAT
AATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References