Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2051989..2052542 Replicon chromosome
Accession NZ_CP092458
Organism Dickeya fangzhongdai strain 643b

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag MJO48_RS09075 Protein ID WP_239788954.1
Coordinates 2052228..2052542 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag MJO48_RS09070 Protein ID WP_042860409.1
Coordinates 2051989..2052225 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJO48_RS09050 (MJO48_09050) 2049065..2049526 - 462 Protein_1769 transposase -
MJO48_RS09055 (MJO48_09055) 2049806..2050135 + 330 Protein_1770 ArdC family protein -
MJO48_RS09060 (MJO48_09060) 2050377..2051333 + 957 WP_239788953.1 group II intron maturase-specific domain-containing protein -
MJO48_RS09065 (MJO48_09065) 2051488..2051820 + 333 Protein_1772 zincin-like metallopeptidase domain-containing protein -
MJO48_RS09070 (MJO48_09070) 2051989..2052225 + 237 WP_042860409.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
MJO48_RS09075 (MJO48_09075) 2052228..2052542 + 315 WP_239788954.1 CcdB family protein Toxin
MJO48_RS09080 (MJO48_09080) 2052539..2052682 - 144 Protein_1775 molybdopterin-guanine dinucleotide biosynthesis protein MobC -
MJO48_RS09090 (MJO48_09090) 2053282..2054073 - 792 WP_100849352.1 DgsA anti-repressor MtfA -
MJO48_RS09100 (MJO48_09100) 2054659..2055006 + 348 WP_038918678.1 DUF3168 domain-containing protein -
MJO48_RS09105 (MJO48_09105) 2055111..2057312 + 2202 WP_239788955.1 discoidin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1999943..2053143 53200
- flank IS/Tn - - 2049026..2049526 500


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11497.43 Da        Isoelectric Point: 6.9736

>T236179 WP_239788954.1 NZ_CP092458:2052228-2052542 [Dickeya fangzhongdai]
MQFTVYDNTGKSVVYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPAGRRPDRLVPVVRLTDGKEYAVMTHELASIPVQALG
AVVCDASQYRTQVKAAIDFLIDGI

Download         Length: 315 bp

>T236179 NZ_LR135477:c4554-3691 [Enterococcus faecium]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAGAATCGCTTAAATGATAATTTAGAAGAATTGATTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACCAGTTTGCGATCAGCAATTT
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGTG
AAACTTTATGAAAAAGACGTAGTAAAACACGTTACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTGAG
CGATCAAGGGTATAATTTGGTGATCGAAGGTACAGGACGAACAACAGACGTTCCTATTCAAACCGCAACAATGCTTCAAG
CCAAAGGTTATGAAACAAAAATGTATGTCATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGATATGAA
ACCATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTATATAACAGAGAAGGAGTAAAACTCTATTCAA
GTTTGGAAACACCTTCTATTAGTCCAAAAGAAACCTTAGAAAAAGAATTGAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTAGAACGAATAGAGCAAAAAATGGTTCTAAATAAACACCAAGAGACACCTGAATTTAAAGCAATTCAACAAAA
ATTGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGTATTTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9067.12 Da        Isoelectric Point: 5.8500

>AT236179 WP_042860409.1 NZ_CP092458:2051989-2052225 [Dickeya fangzhongdai]
MTVKQRNTQSVTMTVERALLVRAREAGINLSATLSTALDAELRRYEAKKWQEENREAIDALNRFHDENGCFSDEYRTF

Download         Length: 237 bp

>AT236179 NZ_LR135477:c4828-4556 [Enterococcus faecium]
ATGGCAGTTACGTATGAAAAAACATTTGAAATAGAGATCATTAACGAATTATCGGCAAGCGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGTTACTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References