236177

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1339194..1339819 Replicon chromosome
Accession NZ_CP092458
Organism Dickeya fangzhongdai strain 643b

Toxin (Protein)


Gene name Hha Uniprot ID E0SD87
Locus tag MJO48_RS06160 Protein ID WP_009114000.1
Coordinates 1339194..1339397 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2K8QJA5
Locus tag MJO48_RS06165 Protein ID WP_042859087.1
Coordinates 1339451..1339819 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJO48_RS06130 (MJO48_06130) 1334833..1335171 + 339 WP_002208627.1 P-II family nitrogen regulator -
MJO48_RS06135 (MJO48_06135) 1335214..1336506 + 1293 WP_038661206.1 ammonium transporter AmtB -
MJO48_RS06140 (MJO48_06140) 1336599..1337462 - 864 WP_239788717.1 acyl-CoA thioesterase II -
MJO48_RS06145 (MJO48_06145) 1337715..1338275 + 561 WP_239788718.1 YbaY family lipoprotein -
MJO48_RS06150 (MJO48_06150) 1338304..1338633 - 330 WP_038918197.1 MGMT family protein -
MJO48_RS06160 (MJO48_06160) 1339194..1339397 - 204 WP_009114000.1 HHA domain-containing protein Toxin
MJO48_RS06165 (MJO48_06165) 1339451..1339819 - 369 WP_042859087.1 Hha toxicity modulator TomB Antitoxin
MJO48_RS06170 (MJO48_06170) 1340327..1340470 - 144 WP_013316871.1 type B 50S ribosomal protein L36 -
MJO48_RS06175 (MJO48_06175) 1340486..1340737 - 252 WP_038661187.1 type B 50S ribosomal protein L31 -
MJO48_RS06180 (MJO48_06180) 1340908..1344054 - 3147 WP_209126376.1 efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8133.51 Da        Isoelectric Point: 8.8500

>T236177 WP_009114000.1 NZ_CP092458:c1339397-1339194 [Dickeya fangzhongdai]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWKYVR

Download         Length: 204 bp

>T236177 NZ_LR135476:49699-50049 [Enterococcus faecium]
ATGGTGAGAAAACCTAGACAAGGCGATATTCTATTATTGAATACAGCACCTCGATCTGGACACGAACAGACAGGTAAAAG
ACCTTATATTGTTTTAAGTCATGATATTATTGCGGATTATAGTAACGTTGTTACAGTTGCTCCAATTTCTAGTACAACTA
GAAACTATCCGCTATATGTAAATATAAACTCAGAATATGAAATGAAGACAACAGGAAAAGTATTATTAGATCAACTAACG
ACAATTGATTATGAAGCCAGAGAGTGTATTTTTTTGGAAAAAGCGCATGATAGTTTAGTTGAGGAGTTATTGATGAAAGT
TAGAACAGTTTTTCAAAAAGTAAGCAAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14200.07 Da        Isoelectric Point: 5.1811

>AT236177 WP_042859087.1 NZ_CP092458:c1339819-1339451 [Dickeya fangzhongdai]
MDEYTPQHYDIAQLRFLCENLHDESIATLGDSSRGWVNDPTSAVNLQLNELIEHIAAFVVTYKIKYPHEAALCERVEKYL
DDTYILFSNYGINDSELQKWKKSKSQLFRMFSEKSICTVVKT

Download         Length: 369 bp

>AT236177 NZ_LR135476:49442-49705 [Enterococcus faecium]
ATGGAAATGTTACCTATAAAAAAATGGGGAAATAGTAATGGCCTTAGATTGCCAAAGTATATTATGGAATATCTTGGAAT
TCATACAGAAGACAAAGTGAAGATAATACAAGAAGAAGTAAACGGTCAGAAGCGGCTAATTATCGAAGCGGCTAATATAG
AAAATGAATTAACAATTGAACAGTTATTTGAAAATTACACTGATGAAAGAAATCATGTGACGATTCAAAATTTAGGTGAA
GCAGTAGGTAATGAAAAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X3RNQ0

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8QJA5

References