Detailed information of TA system TA236175

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 805485..806163
• Replicon: chromosome
• Accession: NZ_CP092458
• Organism: Dickeya fangzhongdai strain 643b

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A2K8QJH4
• Locus tag: MJO48_RS03795
• Protein ID: WP_049854564.1
• Coordinates: 805732..806163 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: MJO48_RS03790
• Protein ID: WP_239789146.1
• Coordinates: 805485..805751 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MJO48_RS03770 (MJO48_03770)	801233..801883	+	651	WP_239788536.1	LysE family translocator	-
MJO48_RS03775 (MJO48_03775)	802625..803233	-	609	WP_239788537.1	HD domain-containing protein	-
MJO48_RS03780 (MJO48_03780)	803444..804094	+	651	WP_038917842.1	hemolysin III family protein	-
MJO48_RS03785 (MJO48_03785)	804194..805174	-	981	WP_239788538.1	tRNA-modifying protein YgfZ	-
MJO48_RS03790 (MJO48_03790)	805485..805751	+	267	WP_239789146.1	FAD assembly factor SdhE	Antitoxin
MJO48_RS03795 (MJO48_03795)	805732..806163	+	432	WP_049854564.1	protein YgfX	Toxin
MJO48_RS03800 (MJO48_03800)	806263..806781	-	519	WP_107758698.1	flavodoxin FldB	-
MJO48_RS03805 (MJO48_03805)	806910..808235	-	1326	WP_038662304.1	MFS transporter	-
MJO48_RS03810 (MJO48_03810)	808498..809397	+	900	WP_038917846.1	site-specific tyrosine recombinase XerD	-
MJO48_RS03815 (MJO48_03815)	809486..810202	+	717	WP_038917847.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-132)

Antitoxin

• Flavinator of succinate dehydrogenase (8-78)

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 16793.54 Da
• Isoelectric Point: 11.7737

>T236175 WP_049854564.1 NZ_CP092458:805732-806163 [Dickeya fangzhongdai]
VAQWQCDLRVSWRMQLFSLLTHGFLVLMILLAPWPDGYAPLWLGLVTLVVFGFVRSQRIIKSRQGEISLHGENQLHWQQR
DWQIARRPWVMRNGVLLSLRATTGKGHQRLWLASDSMGNEEWRLLRQLLLQHPLQGTESSRHH

Nucleotide

• Length: 432 bp

>T236175 NZ_LR135475:c135054-134713 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCCGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTACACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10574.12 Da
• Isoelectric Point: 5.5535

>AT236175 WP_239789146.1 NZ_CP092458:805485-805751 [Dickeya fangzhongdai]
MDINNKSRIHWACRRGMRELDISIMPFFEHEYDTLSDDDKQHFIRLLQCDDPDLFNWLMNHGEPVDPELKRMVSLIQMRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT236175 NZ_LR135475:c135284-135054 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG

Structures

Toxin

• AlphaFold DB: A0A2K8QJH4