Detailed information of TA system TA236173

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 466456..468100
• Replicon: chromosome
• Accession: NZ_CP092458
• Organism: Dickeya fangzhongdai strain 643b

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: MJO48_RS02115
• Protein ID: WP_239788393.1
• Coordinates: 466766..468100 (+)
• Length: 445 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: MJO48_RS02110
• Protein ID: WP_121479599.1
• Coordinates: 466456..466761 (+)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MJO48_RS02090 (MJO48_02090)	462026..463144	+	1119	WP_049855261.1	LPS export ABC transporter permease LptF	-
MJO48_RS02095 (MJO48_02095)	463146..464216	+	1071	WP_161131120.1	LPS export ABC transporter permease LptG	-
MJO48_RS02105 (MJO48_02105)	464712..465968	+	1257	WP_239788392.1	tyrosine-type recombinase/integrase	-
MJO48_RS02110 (MJO48_02110)	466456..466761	+	306	WP_121479599.1	helix-turn-helix transcriptional regulator	Antitoxin
MJO48_RS02115 (MJO48_02115)	466766..468100	+	1335	WP_239788393.1	type II toxin-antitoxin system HipA family toxin	Toxin
MJO48_RS02120 (MJO48_02120)	468376..469464	-	1089	WP_239789134.1	helicase RepA family protein	-
MJO48_RS02125 (MJO48_02125)	469528..470334	-	807	Protein_410	primase-helicase zinc-binding domain-containing protein	-
MJO48_RS02130 (MJO48_02130)	470458..471569	+	1112	WP_121479603.1	IS3 family transposase	-
MJO48_RS02135 (MJO48_02135)	471809..472531	-	723	WP_121479610.1	methyltransferase domain-containing protein	-
MJO48_RS02140 (MJO48_02140)	472539..472796	-	258	WP_038917652.1	YjhX family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (155-406)

Antitoxin

• Cro/C1-type helix-turn-helix domain (20-68)

Sequences

Toxin

Protein

• Length: 445 a.a.
• Molecular weight: 50852.94 Da
• Isoelectric Point: 6.0228

>T236173 WP_239788393.1 NZ_CP092458:466766-468100 [Dickeya fangzhongdai]
MPRTQQRLAIWMNGIQVGFWEKSRGEDRLQYLPEWIADEQGRPLSLSLLFTPGNQIWRGNVVRDYFDNLLPDSEGIRRRL
ATRYHADSLEPFDLLAELGRDCVGAIQLLNGNEEPTDLFSVKYRPLCDAEIAAILRNTTAALLPGRQDDTDDLRLSIAGA
QEKTALLWHERQWCLPEGSTPTTHIFKLPLGLVGNMQADMSTSVENEWLCSLILKEYGIPVAKTQIAQFEDQKVLVVERF
DRRWSSDQQWIIRLPQEDMCQALGVSPLRKYQSDGGPGISDIMTILSHSEQAEQDKAQFFRAQIIFWLIAATDGHAKNFS
IAIEPQGRYHLTPLYDVLSAWPVIGPRNNQISWQKCKLAMAVRGSSNYYHLYRIQRRHWVNHGELTGLGRRQVEAMMDDI
ISRTPEVIERVSSLLPESFPPELAECVFDGMRQQCGRLQELHRK

Nucleotide

• Length: 1335 bp

>T236173 NZ_LR135474:184259-184525 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAATCGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTGGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11331.14 Da
• Isoelectric Point: 10.5325

>AT236173 WP_121479599.1 NZ_CP092458:466456-466761 [Dickeya fangzhongdai]
MNTVYPLKTLNQLRPLLIGFRKAKGMTQKDVSERLGVTQQTYARLEANPGSASIERLFKVLTVLGVEVVLSSGPRVHFSM
SSSTMEEPEKPIDSPARREKW

Nucleotide

• Length: 306 bp

>AT236173 NZ_LR135474:183996-184259 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACAGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTAGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTGGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA