Detailed information of TA system TA236172

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 1616053..1616706
• Replicon: chromosome
• Accession: NZ_CP092454
• Organism: Acinetobacter sp. AHP123

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: MJX77_RS07765
• Protein ID: WP_252061111.1
• Coordinates: 1616317..1616706 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: N9QPI6
• Locus tag: MJX77_RS07760
• Protein ID: WP_005301304.1
• Coordinates: 1616053..1616310 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MJX77_RS07740	1611564..1612571	+	1008	WP_003653641.1	DNA-directed RNA polymerase subunit alpha	-
MJX77_RS07745	1612590..1612967	+	378	WP_002049717.1	50S ribosomal protein L17	-
MJX77_RS07750	1613149..1614639	+	1491	WP_252061110.1	NAD(P)/FAD-dependent oxidoreductase	-
MJX77_RS07755	1614691..1615863	-	1173	WP_151823161.1	acyl-CoA dehydrogenase family protein	-
MJX77_RS07760	1616053..1616310	+	258	WP_005301304.1	succinate dehydrogenase assembly factor 2	Antitoxin
MJX77_RS07765	1616317..1616706	+	390	WP_252061111.1	hypothetical protein	Toxin
MJX77_RS07770	1617476..1618564	+	1089	WP_013196784.1	hypothetical protein	-
MJX77_RS07775	1618648..1619223	+	576	WP_004789598.1	rhombosortase	-
MJX77_RS07780	1619402..1621597	+	2196	WP_252061112.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15558.97 Da
• Isoelectric Point: 10.1638

>T236172 WP_252061111.1 NZ_CP092454:1616317-1616706 [Acinetobacter sp. AHP123]
MIKELNFELKYSRFSIIFQLFIGLCLVILLYQLLPPMWWLFSLILLSIAFLLFLKQSRISQIAYLDQKSWSVVYLPKKVI
HRVEINKIIDYQLFMVVYFEGASVKVAIIWFDQLPLQYWKKLKVLQKLH

Nucleotide

• Length: 390 bp

>T236172 NZ_LR135449:c5553-4690 [Enterococcus faecium]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAGAATCGCTTAAATGATAATTTAGAAGAATTGATTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACCAGTTTGCGATCAGCAATTT
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGTG
AAACTTTATGAAAAAGACGTAGTAAAACACGTTACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTGAG
CGATCAAGGGTATAATTTGGTGATCGAAGGTACAGGACGAACAACAGACGTTCCTATTCAAACCGCAACAATGCTTCAAG
CCAAAGGTTATGAAACAAAAATGTATGTCATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGATATGAA
ACCATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTATATAACAGAGAAGGAGTAAAACTCTATTCAA
GTTTGGAAACACCTTCTATTAGTCCAAAAGAAACCTTAGAAAAAGAATTGAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTAGAACGAATAGAGCAAAAAATGGTTCTAAATAAACACCAAGAGACACCTGAATTTAAAGCAATTCAACAAAA
ATTGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGTATTTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10282.69 Da
• Isoelectric Point: 4.3805

>AT236172 WP_005301304.1 NZ_CP092454:1616053-1616310 [Acinetobacter sp. AHP123]
MSDEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLTADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELREFIYKLK
QYVHG

Nucleotide

• Length: 258 bp

>AT236172 NZ_LR135449:c5827-5555 [Enterococcus faecium]
ATGGCAGTTACGTATGAAAAAACATTTGAAATAGAGATCATTAACGAATTATCGGCAAGCGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGTTACTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA

Structures

Antitoxin

• AlphaFold DB: N9QPI6