23617

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2178795..2179498 Replicon chromosome
Accession NC_012207
Organism Mycobacterium bovis BCG str. Tokyo 172

Toxin (Protein)


Gene name mazF Uniprot ID G0TLK7
Locus tag JTY_RS10080 Protein ID WP_003409778.1
Coordinates 2178795..2179124 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TLK8
Locus tag JTY_RS21150 Protein ID WP_003409780.1
Coordinates 2179121..2179498 (-) Length 126 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JTY_RS10060 2175178..2176248 + 1071 WP_003899091.1 epoxide hydrolase EphB -
JTY_RS10065 2176245..2176760 + 516 WP_003409718.1 flavin reductase family protein -
JTY_RS10070 2176757..2177818 + 1062 WP_003899092.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
JTY_RS10075 2177815..2178585 + 771 WP_003409775.1 SDR family oxidoreductase -
JTY_RS10080 2178795..2179124 - 330 WP_003409778.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JTY_RS21150 2179121..2179498 - 378 WP_003409780.1 type II toxin-antitoxin system antitoxin MazE5 Antitoxin
JTY_RS10090 2179495..2180085 - 591 WP_003910477.1 SEC-C domain-containing protein -
JTY_RS10095 2180140..2181504 + 1365 WP_011799233.1 HNH endonuclease -
JTY_RS10100 2181659..2182111 - 453 WP_010950636.1 lipoprotein -
JTY_RS10105 2182175..2182576 + 402 WP_003409869.1 hypothetical protein -
JTY_RS10110 2182569..2182751 - 183 WP_003409870.1 hypothetical protein -
JTY_RS10115 2182865..2183215 - 351 WP_003409871.1 hypothetical protein -
JTY_RS10120 2183226..2184128 - 903 WP_003409874.1 hypothetical protein -
JTY_RS10125 2184149..2184340 - 192 WP_003409876.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(7-103)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 110 a.a.        Molecular weight: 11787.82 Da        Isoelectric Point: 8.5361

>T23617 WP_003409778.1 NC_012207:c2179124-2178795 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
VTALPARGEVWWCEMAEIGRRPVVVLSRDAAIPRLRRALVAPCTTTIRGLASEVVLEPGSDPIPRRSAVNLDSVESVSVA
VLVNRLGRLADIRMRAICTALEVAVDCSR

Download         Length: 330 bp

>T23617 NC_012207:c2179124-2178795 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
GTGACCGCACTTCCGGCGCGCGGAGAGGTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGACCAGTCGTCGTGCTGTC
GCGCGATGCCGCGATCCCTCGGCTGCGACGCGCACTTGTCGCGCCCTGCACCACGACCATCCGAGGGCTAGCCAGTGAGG
TTGTTCTTGAACCCGGTTCCGACCCGATCCCGCGCCGTTCCGCGGTGAATTTGGACTCAGTCGAAAGTGTCTCGGTCGCG
GTATTGGTGAATCGGCTTGGCCGCCTCGCCGACATCCGGATGCGCGCCATCTGCACGGCCCTCGAGGTCGCCGTCGATTG
CTCTCGATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13560.07 Da        Isoelectric Point: 5.1519

>AT23617 WP_003409780.1 NC_012207:c2179498-2179121 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
VKTARLQVTLRCAVDLINSSSDQCFARIEHVASDQADPRPGVWHSSGMNRIRLSTTVDAALLTSARDMRAGITDAALIDE
ALAALLARHRSAEVDASYAAYDKHPVDEPDEWGDLASWRRAAGDS

Download         Length: 378 bp

>AT23617 NC_012207:c2179498-2179121 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
GTGAAGACGGCCCGGTTGCAGGTGACGTTGCGCTGCGCGGTAGACCTCATCAATTCGTCCAGCGACCAATGTTTCGCCCG
TATCGAGCACGTTGCGTCCGATCAGGCGGATCCACGCCCCGGAGTGTGGCATAGTAGTGGCATGAATCGCATACGGCTGA
GCACTACTGTCGACGCCGCACTCTTGACAAGTGCGCGCGACATGCGGGCAGGAATCACTGACGCAGCCCTCATCGATGAG
GCCCTTGCGGCATTACTGGCTCGTCATCGATCGGCCGAGGTGGATGCCAGCTATGCGGCCTACGACAAGCACCCGGTCGA
TGAGCCCGACGAGTGGGGCGATCTAGCGTCGTGGCGGCGGGCGGCTGGAGACTCGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TLK7


Antitoxin

Source ID Structure
AlphaFold DB G0TLK8

References