Detailed information of TA system TA236169

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3966411..3967243
• Replicon: chromosome
• Accession: NZ_CP092452
• Organism: Escherichia coli isolate TKEC21-59

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: MJJ11_RS19300
• Protein ID: WP_239812913.1
• Coordinates: 3966411..3966785 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: S1NM52
• Locus tag: MJJ11_RS19305
• Protein ID: WP_001295723.1
• Coordinates: 3966875..3967243 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MJJ11_RS19260 (3961610)	3961610..3962716	+	1107	WP_001315214.1	N-acetylneuraminate epimerase	-
MJJ11_RS19265 (3962781)	3962781..3963761	+	981	WP_239812911.1	sialate O-acetylesterase	-
MJJ11_RS19270 (3963769)	3963769..3964419	-	651	WP_239812912.1	HNH endonuclease	-
MJJ11_RS19275 (3964556)	3964556..3964699	+	144	Protein_3791	HNH endonuclease	-
MJJ11_RS19280 (3964798)	3964798..3964983	+	186	WP_000066585.1	hypothetical protein	-
MJJ11_RS19285 (3965475)	3965475..3965624	-	150	Protein_3793	hypothetical protein	-
MJJ11_RS19290 (3965730)	3965730..3965906	-	177	WP_000839290.1	DUF957 domain-containing protein	-
MJJ11_RS19295 (3965923)	3965923..3966414	-	492	WP_000976842.1	DUF5983 family protein	-
MJJ11_RS19300 (3966411)	3966411..3966785	-	375	WP_239812913.1	TA system toxin CbtA family protein	Toxin
MJJ11_RS19305 (3966875)	3966875..3967243	-	369	WP_001295723.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
MJJ11_RS19310 (3967406)	3967406..3967627	-	222	WP_000692345.1	DUF987 domain-containing protein	-
MJJ11_RS19315 (3967696)	3967696..3968172	-	477	WP_032263694.1	RadC family protein	-
MJJ11_RS19320 (3968188)	3968188..3968661	-	474	WP_053895489.1	antirestriction protein	-
MJJ11_RS19325 (3969003)	3969003..3969821	-	819	WP_001234651.1	DUF932 domain-containing protein	-
MJJ11_RS19330 (3969974)	3969974..3970132	-	159	WP_001323397.1	DUF905 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimE / fimB	3956967..3981646	24679

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13985.01 Da
• Isoelectric Point: 7.2909

>T236169 WP_239812913.1 NZ_CP092452:c3966785-3966411 [Escherichia coli]
MKTLPDTHVRELSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK

Nucleotide

• Length: 375 bp

>T236169 NZ_LR135444:c217565-217293 [Enterococcus faecium]
ATGAATAACTATTCTGTGATGATTAAAAACTCGGCTAAAGCTGATTTAAAGAAAATCAAACAGTCTAATTTGAAACCTCA
ATTTGAGAAGGTTATTCAGACTTTAAAGGAAGATCCCTATCTCCCTACCCAATCATTTGAGAAGTTAAAACCTACACATG
AAGGTAGGTATTCTAGAAGATTGAATAGACAACACCGGGTTGTTTATAAGGTAGATGAAGATGAACACGTGGTTGAAATT
TATTCAGCAAGGACGCATTACGAGTCACAGTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13592.40 Da
• Isoelectric Point: 6.6255

>AT236169 WP_001295723.1 NZ_CP092452:c3967243-3966875 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT236169 NZ_LR135444:c217828-217565 [Enterococcus faecium]
ATGGCAAAAACAGTCTTAAATCCTAGCTCAGCACGGAAAAATTTTTATAAGTTGTTGAAAGATGTAAATGAGAATCATAC
GGAAATTGAAATCATTAGTGAGCGCAGTGAAAATAATGCGGTGCTTATTGGTTTGGATGATTGGAAAGCAATCAAAGAAA
CGCTATTACTTGAGCAAATAGGCACTTTGGGTGTTGTTCGTAAGCGAGAAAAAGATGATAGTGGATTTACTAATGTTGAT
GAAATTGATTGGGATAACTTATAA

Structures

Antitoxin

• AlphaFold DB: S1NM52