Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1945766..1946226 Replicon chromosome
Accession NC_012207
Organism Mycobacterium bovis BCG str. Tokyo 172

Toxin (Protein)


Gene name vapC Uniprot ID A0A7U4FB26
Locus tag JTY_RS09055 Protein ID WP_003408531.1
Coordinates 1945978..1946226 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag JTY_RS09050 Protein ID WP_003408528.1
Coordinates 1945766..1945978 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JTY_RS09035 1942244..1943431 - 1188 WP_003898992.1 nitrate transporter NarK -
JTY_RS09040 1943718..1944002 + 285 WP_003408522.1 DUF1876 domain-containing protein -
JTY_RS09045 1944016..1945698 - 1683 WP_003898994.1 SulP family inorganic anion transporter -
JTY_RS09050 1945766..1945978 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JTY_RS09055 1945978..1946226 + 249 WP_003408531.1 hypothetical protein Toxin
JTY_RS09060 1946234..1946972 + 739 Protein_1765 hypothetical protein -
JTY_RS09065 1947066..1948766 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
JTY_RS09070 1949051..1949452 - 402 WP_010950586.1 hypothetical protein -
JTY_RS09075 1949523..1950053 - 531 WP_011799212.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8857.07 Da        Isoelectric Point: 3.9794

>T23616 WP_003408531.1 NC_012207:1945978-1946226 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYTGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T23616 NC_012207:1945978-1946226 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATACGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT23616 WP_003408528.1 NC_012207:1945766-1945978 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT23616 NC_012207:1945766-1945978 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB26

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References