Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 872001..872655 Replicon chromosome
Accession NZ_CP092452
Organism Escherichia coli isolate TKEC21-59

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag MJJ11_RS04320 Protein ID WP_239812938.1
Coordinates 872248..872655 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag MJJ11_RS04315 Protein ID WP_000354046.1
Coordinates 872001..872267 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJJ11_RS04290 (867170) 867170..867913 + 744 WP_000951948.1 SDR family oxidoreductase -
MJJ11_RS04295 (867970) 867970..869403 - 1434 WP_001338826.1 6-phospho-beta-glucosidase BglA -
MJJ11_RS04300 (869448) 869448..869759 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
MJJ11_RS04305 (869923) 869923..870582 + 660 WP_000250274.1 hemolysin III family protein -
MJJ11_RS04310 (870778) 870778..871758 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
MJJ11_RS04315 (872001) 872001..872267 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
MJJ11_RS04320 (872248) 872248..872655 + 408 WP_239812938.1 protein YgfX Toxin
MJJ11_RS04325 (872695) 872695..873216 - 522 WP_001055874.1 flavodoxin FldB -
MJJ11_RS04330 (873328) 873328..874224 + 897 WP_000806639.1 site-specific tyrosine recombinase XerD -
MJJ11_RS04335 (874249) 874249..874959 + 711 WP_000715216.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MJJ11_RS04340 (874965) 874965..876698 + 1734 WP_063119319.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16045.99 Da        Isoelectric Point: 11.5202

>T236152 WP_239812938.1 NZ_CP092452:872248-872655 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLLAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T236152 NZ_LR135414:198213-198479 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTAGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT236152 WP_000354046.1 NZ_CP092452:872001-872267 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT236152 NZ_LR135414:197950-198213 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTGGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTAGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References