Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1925148..1925761 Replicon chromosome
Accession NC_012207
Organism Mycobacterium bovis BCG str. Tokyo 172

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag JTY_RS08945 Protein ID WP_003408465.1
Coordinates 1925148..1925537 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag JTY_RS08950 Protein ID WP_003408469.1
Coordinates 1925534..1925761 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JTY_RS08915 1920778..1921692 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
JTY_RS08920 1921695..1922525 + 831 WP_003408448.1 cyclase family protein -
JTY_RS08925 1922525..1922875 + 351 WP_003898986.1 cupin domain-containing protein -
JTY_RS08930 1922928..1923745 + 818 Protein_1740 3-keto-5-aminohexanoate cleavage protein -
JTY_RS08935 1923759..1924538 + 780 WP_003408460.1 IclR family transcriptional regulator -
JTY_RS08945 1925148..1925537 - 390 WP_003408465.1 PIN domain-containing protein Toxin
JTY_RS08950 1925534..1925761 - 228 WP_003408469.1 antitoxin Antitoxin
JTY_RS08955 1925979..1927463 + 1485 WP_010950580.1 biotin carboxylase -
JTY_RS08960 1927460..1928707 + 1248 WP_003408476.1 serine hydrolase -
JTY_RS08965 1928750..1929169 - 420 WP_003408483.1 hypothetical protein -
JTY_RS08970 1929159..1929869 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T23615 WP_003408465.1 NC_012207:c1925537-1925148 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T23615 NC_012207:c1925537-1925148 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT23615 WP_003408469.1 NC_012207:c1925761-1925534 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT23615 NC_012207:c1925761-1925534 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References