Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 872777..873431 Replicon chromosome
Accession NZ_CP092449
Organism Escherichia coli isolate TKEC21-17

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag MJJ13_RS04325 Protein ID WP_239812938.1
Coordinates 873024..873431 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag MJJ13_RS04320 Protein ID WP_000354046.1
Coordinates 872777..873043 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJJ13_RS04295 (867946) 867946..868689 + 744 WP_000951948.1 SDR family oxidoreductase -
MJJ13_RS04300 (868746) 868746..870179 - 1434 WP_001338826.1 6-phospho-beta-glucosidase BglA -
MJJ13_RS04305 (870224) 870224..870535 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
MJJ13_RS04310 (870699) 870699..871358 + 660 WP_000250274.1 hemolysin III family protein -
MJJ13_RS04315 (871554) 871554..872534 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
MJJ13_RS04320 (872777) 872777..873043 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
MJJ13_RS04325 (873024) 873024..873431 + 408 WP_239812938.1 protein YgfX Toxin
MJJ13_RS04330 (873471) 873471..873992 - 522 WP_001055874.1 flavodoxin FldB -
MJJ13_RS04335 (874104) 874104..875000 + 897 WP_000806639.1 site-specific tyrosine recombinase XerD -
MJJ13_RS04340 (875025) 875025..875735 + 711 WP_000715216.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MJJ13_RS04345 (875741) 875741..877474 + 1734 WP_063119319.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16045.99 Da        Isoelectric Point: 11.5202

>T236129 WP_239812938.1 NZ_CP092449:873024-873431 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLLAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T236129 NZ_LR135365:45704-46054 [Enterococcus faecium]
ATGGTGAGAAAACCTAGACAAGGCGATATTCTATTATTGAATACAGCACCTCGATCTGGACACGAACAGACAGGTAAAAG
ACCTTATATTGTTTTAAGTCATGATATTATTGCGGATTATAGTAACGTTGTTACAGTTGCTCCAATTTCTAGTACAACTA
GAAACTATCCGCTATATGTAAATATAAACTCAGAATATGAAATGAAGACAACAGGAAAAGTATTATTAGATCAACTAACG
ACAATTGATTATGAAGCCAGAGAGTGTATTTTTTTGGAAAAAGCGCATGATAGTTTAGTTGAGGAGTTATTGATGAAAGT
TAGAACAGTTTTTCAAAAAGTAAGCAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT236129 WP_000354046.1 NZ_CP092449:872777-873043 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT236129 NZ_LR135365:45447-45710 [Enterococcus faecium]
ATGGAAATGTTACCTATAAAAAAATGGGGAAATAGTAATGGCCTTAGATTGCCAAAGTATATTATGGAATATCTTGGAAT
TCATACAGAAGACAAAGTGAAGATAATACAAGAAGAAGTAAACGGTCAGAAGCGGCTAATTATCGAAGCGGCTAATATAG
AAAATGAATTAACAATTGAACAGTTATTTGAAAATTACACTGATGAAAGAAATCATGTGACGATTCAAAATTTAGGTGAA
GCAGTAGGTAATGAAAAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References