Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2032107..2032621 Replicon chromosome
Accession NZ_CP092447
Organism Staphylococcus aureus strain SYN

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag LXM97_RS09785 Protein ID WP_000581792.1
Coordinates 2032107..2032316 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag LXM97_RS09790 Protein ID WP_000138934.1
Coordinates 2032328..2032621 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXM97_RS09765 (LXM97_09765) 2027615..2028973 - 1359 WP_000611468.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
LXM97_RS09770 (LXM97_09770) 2028988..2030058 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
LXM97_RS09775 (LXM97_09775) 2030376..2031578 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
LXM97_RS09780 (LXM97_09780) 2031842..2031979 - 138 WP_000828354.1 Lmo0850 family protein -
LXM97_RS09785 (LXM97_09785) 2032107..2032316 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
LXM97_RS09790 (LXM97_09790) 2032328..2032621 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
LXM97_RS09795 (LXM97_09795) 2032787..2034271 + 1485 WP_000571549.1 cardiolipin synthase -
LXM97_RS09800 (LXM97_09800) 2034299..2034946 + 648 WP_001187610.1 HD domain-containing protein -
LXM97_RS09805 (LXM97_09805) 2035761..2036633 - 873 WP_000725802.1 membrane protein insertase YidC -
LXM97_RS09810 (LXM97_09810) 2036719..2037360 - 642 WP_000483147.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T236121 WP_000581792.1 NZ_CP092447:c2032316-2032107 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T236121 NZ_LR135352:c223954-223682 [Enterococcus faecium]
ATGAATAACTATTCTGTGATGATTAAAAACTCGGCTAAAGCTGATTTAAAGAAAATCAAACAGTCTAATTTGAAACCTCA
ATTTGAGAAGGTTATTCAGACTTTAAAGGAAGATCCCTATCTCCCTACCCAATCATTTGAGAAGTTAAAACCTACACATG
AAGGTAGGTATTCTAGAAGATTGAATAGACAACACCGGGTTGTTTATAAGGTAGATGAAGATGAACACGTGGTTGAAATT
TATTCAGCAAGGACGCATTACGAGTCACAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT236121 WP_000138934.1 NZ_CP092447:c2032621-2032328 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT236121 NZ_LR135352:c224217-223954 [Enterococcus faecium]
ATGGCAAAAACAGTCTTAAATCCTAGCTCAGCACGGAAAAATTTTTATAAGTTGTTGAAAGATGTAAATGAGAATCATAC
GGAAATTGAAATCATTAGTGAGCGCAGTGAAAATAATGCGGTGCTTATTGGTTTGGATGATTGGAAAGCAATCAAAGAAA
CGCTATTACTTGAGCAAATAGGCACTTTGGGTGTTGTTCGTAAGCGAGAAAAAGATGATAGTGGATTTACTAATGTTGAT
GAAATTGATTGGGATAACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References